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Lifespan with Dr. David Sinclair

Lifespan Communications LLC

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Join Dr. David Sinclair, Ph.D. in Lifespan, a popular health podcast that brings the cutting edge of aging and longevity science straight to you. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. This podcast is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for med ...
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On Lifespan, you’ll hear stories about encounters with the health care system. Each show contains stories bound by a common theme – a person’s personal journey through a particular type of medical trauma. The stories are deeply personal. Some stories reflect a person’s response to treatment and other stories simply reflect on the aftermath of an illness. Even when multiple people are describing their experiences with the same disease, condition or treatment, each account is unique. If the su ...
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Larry and Carol have been married for 66 years. About 17 years ago, Carol began to show signs of memory problems. She has since been diagnosed as having Alzheimer’s. In this episode of Lifespan, Larry, and his daughter, Madeline, who are both physicians, talk about Carol and the difficulties that Alzheimer’s presents to everyone touched by the illn…
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When someone suspects they have a tumor, the first thing they think about, and fear, is cancer. So, when their biopsy comes back as “benign,” they’re relieved. But the word “benign” can be deceptive. In this episode of Lifespan, our guest, Deidre Naughton, describes her experience with painful, recurring, non-cancerous tumors.…
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In the final episode of this season, Dr. David Sinclair and Matthew LaPlante focus on current and near-future technologies relevant to health and aging. In addition to discussing the utility of wearable sensors and biological age measurements, they highlight innovative research aimed at reversing biological age. The societal effects of therapies th…
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In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discusse…
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In Episode 6 of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante discuss cosmetic aging and how to improve skin, nails, and hair. They talk about why superficial aging occurs and how external signs of aging are often a reflection of biological age. The latest science behind various beautifying therapies is highlighted, includin…
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In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogrammin…
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In this week’s episode, Dr. David Sinclair and co-host Matthew LaPlante zero in on drugs and supplements that have been reported to combat aspects of aging. They share the latest experimental and clinical data for NAD boosters, resveratrol, fisetin, quercetin, rapamycin, spermidine, metformin, and berberine. Given the abundance of data available, a…
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In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect agai…
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In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss how frequently we should eat, what food we should avoid, and what food we should pursue. They discuss the science behind how a "low energy state," which can be induced by a period of fasting, combats aging and promotes health. They also walk through research that points to the…
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In this episode, Dr. David Sinclair and co-host Matthew LaPlante discuss why we age. In doing so, they discuss organisms that have extreme longevity, the genes that control aging (mTOR, AMPK, Sirtuins), the role of sirtuin proteins as epigenetic regulators of aging, the process of "ex-differentiation" in which cells begin to lose their identity, an…
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Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School's Paul F. Glenn Center for Biology of Aging Research. Season 1 will be 8 episodes in total and will launch on Wednesday, January 5, 2022. New episodes will be released every Wednesday morning of both January and Febru…
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“‘Breast cancer awareness’ is a national catchphrase. There is less recognition, however, of testicular cancer, even though the average age for onset is 33, far younger than for breast cancer. At 33, few men worry about cancer and so they tend to ignore any signs of the illness. In this episode of Lifespan, Dan Skinner, a professor of health policy…
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Faiza Aziz is a medical student. Before enrolling in medical school in 2020, given her public health and medical knowledge, her fluency in several languages, and her familiarity with several cultures, she trained and worked as a medical interpreter. In this episode of Lifespan, Faiza describes the vital role played by medical interpreters in the he…
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Bob Simpson and Estelle Carol have been together for almost 50 years. They have two grown children. Before retirement, Bob was a high school history teacher. Estelle is still working as a graphic designer. For decades, they also combined their talents to produce syndicated political cartoons under the byline Carol Simpson. Then, in 2016, Bob had a …
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Chris Kaposy and Jan Beattie have three children: Elizabeth, 14, Aaron, 11, and Ty, 7. With each pregnancy, Jan and Chris decided in advance to refuse prenatal testing. But when Jan was pregnant with Aaron, her first ultrasound at 19 weeks showed some markers for Down syndrome and she and Chris had to revisit their original decision about prenatal …
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Anna Mehler Paperny is a Canadian journalist who has worked for Reuters, The Globe and Mail, and Global News. She’s won awards for her investigative journalism. And she’s struggled with major clinical depression for most of her adult life, attempting suicide several times. On this episode of Lifespan, Anna talks about her experience of mental illne…
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Steve Bild, Renee Pollock, and Mary Costello have all lost their longtime spouses. In this episode of Lifespan, they describe their spouses’ lives and legacies, their partners’ deaths, and their own adjustment to living in the aftermath of grievous loss. Steve, Renee, and Mary also offer advice to others coping with similarly profound loss. If you …
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Debbie and Doug have been married for more than 40 years. In this episode of Lifespan, Doug talks candidly about his addiction to alcohol and his ongoing recovery. Debbie describes the meaning and effect of co-dependence, and the invaluable help she received from Al-Anon. Doug is now a substance abuse counselor, so his description of his recovery o…
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In the last 16 years, Bernhard Debatin has had three different types of cancer. Physicians in Germany treated his first cancer successfully; physicians in the United States successfully treated the other two. In this episode of Lifespan, Bernhard describes patients’ experience of cancer and its aftermath, and reflects on how culture, healthcare sys…
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We all know how sick we feel when our stomach is upset. We’ve all experienced nausea, diarrhea, and stomach pain—among the most uncomfortable symptoms we can have when we’re sick. But chronic gastro-intestinal disease and serious episodic gastro-intestinal disease take stomach discomfort to an entirely different level. On this episode of Lifespan, …
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Last month, Jackie Wolf talked to three women, Lauren, Stacy, and Cora, who were pregnant for the first time. On this month’s episode of Lifespan, Jackie talks to them again—this time about their births. It turns out that the medical treatment and advice they received during their pregnancies set the agenda for how their babies were born. And the t…
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On this episode of Lifespan, Jackie Wolf talks to three women who will soon give birth for the first time. Their experiences during pregnancy have differed because each woman received a different medical label. Doctors identified Lauren, at age 36, as “a geriatric pregnancy.” Stacy struggled with infertility before becoming pregnant. And Cora, desp…
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Medical students of color shoulder a double burden. They are medical students, expected to do all the hard work that goes with being a medical student. And each day they also must cope with, and find ways to respond to, racism in the classroom and the clinic. They don’t have the luxury of simply being medical students. On this episode of Lifespan, …
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One deceased organ donor can save up to 8 lives. Yet, on average, 20 people on the United Network for Organ Sharing waiting list die each day because so few organs are available. On this episode of Lifespan, we hear from Kelly Nottingham, who donated a kidney to her mother; David Burke, who received a liver from a deceased donor; and Cynthia Tindon…
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Burns are among the most difficult injuries for physicians to treat. Our skin isn’t just our appearance to the world, skin helps to regulate body temperature, prevent infection, and ensure that fluids move smoothly from one part of our body to the other. When our skin is severely damaged, especially if the damage is widespread third- and fourth-deg…
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Lifespan host Jackie Wolf’s mother died of lung cancer in 2010. In this episode of Lifespan, she uses the story of her mother’s illness and death as an example of end-of-life care in the United States. The American approach to end-of-life care is often characterized by futile treatment at enormous cost. It also tends to favor quantity over quality …
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Chronic illness is, by definition, treatable but not curable. In this episode of Lifespan, Jennifer Grayson describes her struggle, beginning in high school, with unexplained symptoms. Emily Abel talks about her experience with post-cancer fatigue. Mary Ellen Croteau explains how a chronic respiratory condition impacted her work as an artist. Katy …
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Sudden, catastrophic illnesses often perplex doctors and terrify patients. In Doug Mann’s case, doctors at multiple medical centers could not figure out why he was experiencing a rapidly spreading paralysis in his legs. Months passed before he received a proper diagnosis and appropriate treatment.
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We hear it all the time: “breastfeeding is the most natural thing in the world.” But as you’ll learn from these stories, today’s breastfeeding mothers are running into difficulties. Sarah Rubin had been prepared to battle the medicalization of birth but had not anticipated the medicalization of breastfeeding. Clare Chambers was unprepared for sleep…
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On Lifespan, you’ll hear stories about encounters with the health care system. Each show contains stories bound by a common theme: chronic illness, substance abuse, end-of-life care—the topics will keep coming. The stories are deeply personal. Some suggest the best approaches to handling or treating an illness. Other stories simply reflect on an il…
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