“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Eac ...
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Battle of the Heart Valves: 🔍: Myval Matches, ACURATE Misses ❌, SAPIEN Stands Strong 💪
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5:50🚨 TAVI Trials Update! 🆚 COMPARE-TAVI 1: 🇮🇳Myval = 💪SAPIEN 3 in safety & efficacy 🆚 ACURATE IDE: ACURATE neo2 ❌not non-inferior to 💥SAPIEN/EVOLUT 📊 Valve wars intensify! #TAVI #HeartValve #Cardiology 🫀על ידי MasterMedFacts LLC
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“Not All Heat Is Equal: Science Behind the Chili Burn 🌡️🧠🌶️”
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3:07🌶️ Not all chili heat is created equal! Scientists found hidden compounds—like capsianoside I & roseoside—that cool the burn without changing flavor 🔬❄️ Your next spicy dish might be hot… but not hurt. #FlavorScience #Capsaicin #TRPV1 #FoodTech 🍽️🧠🔥על ידי MasterMedFacts LLC
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🚨 Tiny Twists, Big Clues: Vortices Reveal Chemotherapy’s Toll
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4:05📊 New study shows Topological Flow Data Analysis (TFDA) 🌀 detects early cardiac dysfunction in childhood cancer survivors—before LVEF or strain drop! 🔍 A game-changer in cardio-onc surveillance. #CardioOncology #TFDA #EchoRevolutionעל ידי MasterMedFacts LLC
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“COPD patients: Choked by Mucus Plugs? 📉💨🧪”
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2:32📉 Mucus plugs matter! In COPD, persistent or new plugs accelerate FEV₁ decline 🫁💨 🖥️ CT imaging tracks their impact 🚬 Smoking worsens the hit 👉 Clear the plugs, preserve the lungs! #COPD #LungHealth #NEJM #FEV1 #Pulmonologyעל ידי MasterMedFacts LLC
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💥 Old Drugs, New Power: Amiloride vs Spironolactone in Resistant Hypertension
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4:24🩺 New hope for #ResistantHypertension! A 12-week RCT 🇰🇷 shows 💊 amiloride is noninferior to spironolactone in lowering SBP 📉 Fewer side effects, similar BP drop! But spironolactone may still reign 👑 for organ protection 🫀🧠 🧪 #Hypertension #Cardiology #JAMA2025על ידי MasterMedFacts LLC
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🧪 Precision for One, Promise for Many: CRISPR Meets the Clinic--A New Era in Rare Disease Therapy
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6:43🧬✨ A baby with deadly CPS1 deficiency (which results in elevated ammonia levels) gets a custom-made gene edit—delivered by lipid nanoparticles—in just 6 months! 🚀 Ammonia levels down, no hospitalizations, and hope up. N-of-1? More like Future-of-Many. 💡👶🔬 #GeneTherapy #PrecisionMedicine #RareDiseaseעל ידי MasterMedFacts LLC
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🔥 Smoldering Systems: Staging Systemic Metabolic Disorder Before It Ignites
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3:40🚨 New framework alert! Systemic Metabolic Disorder (SMD) gets a clinical staging makeover 🧬 From reversible risks 🌱 to systemic damage 🔥—this EAS consensus guides timely, targeted care 🎯 #MetabolicHealth #Cardiology #PrecisionMedicine #SMD 🩺📊על ידי MasterMedFacts LLC
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Dr RR Baliga's Philosophical Discourses: Pyrrho (Greece, c. 360–270 BCE) – Founder of Pyrrhonism
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4:16Pyrrho of Elis (c. 360–270 BCE) was an ancient Greek philosopher and founder of Pyrrhonism, a school of philosophical skepticism. He advocated for epoché (suspension of judgment) as a path to ataraxia (peace of mind). Influenced by his travels to India with Alexander the Great, Pyrrho believed that nothing could be definitively known and that by re…
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🧬 Target ANGPTL3, Tame the Lipids, Transform the Risk
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4:55🧬 New hope for lipid warriors! Solbinsiran (siRNA) slashed apoB 🩸, TGs 🍟, LDL-C 💔 & liver fat 🫀 in just 205 pts with mixed dyslipidaemia. Safe ✅ Durable ✅ Quarterly dosing? Maybe ✅ Let’s talk outcomes! 🎯 #PROLONGANG3 #RNAtherapy #CardioTwitter #LipidLoweringעל ידי MasterMedFacts LLC
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🏥 Watch, Wait, or Wage War? The Prostate Cancer Playbook
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3:41🧔♂️ Prostate cancer is the most common cancer in US men. 🧪 PSA testing? 🔍 It’s all about shared decision-making. 🧬 From Gleason scores to PSMA-PET, precision reigns. 💉 ARPIs & ADT = survival gains in advanced disease. ⚖️ Screen smart. Treat right. Save lives. #ProstateCancer #MensHealth #Oncology 🧠💪…
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Triglycerides, Trials, and Triumph 🚧📉🏆: The ANGPTL4 Story
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5:32🚨 New frontier in lipid-lowering! 🧬 Blocking ANGPTL4 with MAR001 slashed triglycerides & remnant cholesterol by >50% 🛡️ Safe, well-tolerated, no lymph node issues 💡 Promising for residual ASCVD risk Next step? Big trials, big answers! 📊🫀 #LipidScience #CardioTwitter #PrecisionMedicineעל ידי MasterMedFacts LLC
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Cracking the Code of Short Sleepers 🧠🔍😴
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3:16Why do some people sleep just 4 hours and feel great? 😴💪 A new study links the 🧬 SIK3-N783Y mutation to natural short sleep! Less sleep, more delta power 🧠⚡ 🚀🛌 #SleepScience #Genetics #SIK3 #ShortSleepersעל ידי MasterMedFacts LLC
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🔥 IL-6, Inflammation, and Irregular Beats: The Cytokine Cascade Driving Post-Op AFib
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4:01🫀 Post-op AFib? Blame IL-6! New @JClinInvest study shows IL-6 ➡️ STAT3 ➡️ CaMKII ➡️ RyR2 leak triggers post-op AFib. 🧬 Macrophage IL-6Rα is the match. 🧯 TTI-101 & KN-93 douse the flame. ⚡ Targeting IL-6 signaling = future Rx? #CardioTwitter #AFib #Inflammation #JCIעל ידי MasterMedFacts LLC
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Good Carbs, Great Life, Golden Years 🥦✨👵
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4:24🥦🍎 Want to age like fine wine? Choose high-quality carbs! In a 32-year study of 47K women, fiber-rich carbs (from 🌾, 🥗, 🌱) boosted odds of healthy aging 🧠💪🧘♀️ Refined carbs? Not so kind. #HealthyAging #NutritionMatters #WomensHealth 🧬📊💚על ידי MasterMedFacts LLC
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MRI Matters 🧲: Imaging the Silent Duo — Heart & Liver 🫀
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4:19🧠🫀🧫 New study in Nature Medicine shows that multiorgan MRI predicts both 💔 cardiovascular and 🩸 liver events. Cardiac (LVEF ≤50%) + Liver (cT1 ≥800ms) = 🚨 higher risk & earlier events. Integrated imaging = smarter prevention! 🔍📊 #Cardiology #Hepatology #MRI #MASLD #CVDעל ידי MasterMedFacts LLC
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💪 Immunotherapy Power Duo: Nivolumab + Ipilimumab vs. TKIs in HCC
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4:17🚀 New Breakthrough in Liver Cancer! 🌟 The CheckMate 9DW trial shows that Nivolumab + Ipilimumab significantly improves survival in unresectable #HCC compared to lenvatinib/sorafenib! 🧬💪 #Immunotherapy #CancerResearch #LiverCancer #Oncology 💉על ידי MasterMedFacts LLC
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💔 AF, Ablation, and Brain Clean-Up by Glymphatics: Fact or Fiction?
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4:43🧠💔 Atrial Fibrillation (AF) disrupts brain glymphatic function, leading to cognitive decline! 😓 Catheter ablation may help restore rhythm and brain clearance. More research needed! 📊 #Cardiology #BrainHealth #AF #Cognition 💡על ידי MasterMedFacts LLC
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🧠 Clearing the mind: How Glymphatics & Lymphatics Clear the Mind
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2:32🧠💡 New Insights! The brain isn’t as “immune privileged” as once thought! 🌊🔄 Glymphatics & meningeal lymphatics reveal how the CNS clears waste & connects to immunity. 🦠 Aging & neurodegeneration challenge this balance. #Neuroscience #Immunology #BrainHealth 🧬🚀על ידי MasterMedFacts LLC
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TR Troubles 🌟: Progress, Pitfalls, and Patient Selection
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3:10🚦 Tricuspid Regurgitation (TR) Troubles! 💔 Despite promising interventions, recent trials show no survival benefit. Patient selection & procedural success are key! 📝 Focus on quality of life, not just longevity. #Cardiology #HeartHealth #TRManagement 💙על ידי MasterMedFacts LLC
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Food as Medicine: Unleashing the Hidden Therapeutic Power of Nutrition Dark Matter 🌱💊
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3:37🌱💊 Unlocking the Power of Food! #NutritionDarkMatter holds 139,000+ molecules with therapeutic potential. 🍎 AI-driven research is paving the way for #PrecisionNutrition & innovative healthcare solutions! 🌟 #FoodAsMedicine #HealthRevolution 🚀על ידי MasterMedFacts LLC
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🚧 Stents vs Scalpels: The FAME 3 Face-Off 🩺⚔️
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4:17🚨 FAME 3 at 5 years: FFR-guided PCI 🛠️ vs CABG 🫀 in 3-vessel CAD — no difference in death/stroke, but more MI & revascularization with PCI ⚠️. Heart team matters 🤝. #CardioTwitter #FAME3 #Revascularization 🩺📊על ידי MasterMedFacts LLC
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Dr RR Baliga's Philosophical Discourses: Zeno of Citium (Greece, c. 334–262 BCE) – Founder of Stoicism
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3:28Zeno of Citium (c. 334 – c. 262 BC) was a Hellenistic philosopher from Cyprus and the founder of Stoicism. His philosophy emphasized living in harmony with nature and practicing virtue to attain peace of mind (ataraxia). Zeno’s teachings influenced ethics, logic, and natural philosophy, laying the foundation for Stoicism’s prominence during the Rom…
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🫀 Flow vs Form 🛠️: Guiding PCI with FFR or IVUS in the FLAVOUR II Trial 🎯
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3:49🚨 New from #FLAVOURII: Angio-FFR vs IVUS to guide PCI 🫀 🎯 Similar outcomes 📉 Fewer stents 🧠 Smarter decisions Is flow-based guidance the future? 🌍 #CardioTwitter #FFR #IVUS #Intervention 📰 Lancet 2025 | 📊 RCT | 🇨🇳 1839 patientsעל ידי MasterMedFacts LLC
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🚀 Next-Gen Weight Loss: Tirzepatide’s Winning Edge Over Semaglutide
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3:07🚀 Tirzepatide Triumphs! 💪 In a head-to-head trial, #Tirzepatide led to greater weight loss (-20.2%) compared to #Semaglutide (-13.7%) over 72 weeks! 📉🌟 Superior waist reduction too! #ObesityManagement #WeightLoss #GLP1 #GIP 🩺💊 #CardiometabolicHealth #ClinicalResearchעל ידי MasterMedFacts LLC
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Head Hits, Heart Risks: Concussions in Football Spike Cardiovascular Danger 🏈❤️
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3:19🏈💥 Concussions in football don’t just hit the brain—they impact the heart too! 📈🫀 New study shows increased BP, arterial stiffness, and cardiac risks in NCAA athletes post-concussion. 🧠➡️❤️ #Cardiology #SportsMedicine #ConcussionRisk #HeartHealthעל ידי MasterMedFacts LLC
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🦠 Microbes, Mutations, and Malignancy: Unveiling the Gut–Blood Cancer Axis 💉
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4:02🧬 A molecule from aging gut bacteria—ADP-heptose—enters the bloodstream, activates ALPK1, and triggers NF-κB signaling, driving the expansion of mutant blood stem cells. 🦠🧓 This discovery links gut health to leukemia risk and reveals new targets like ALPK1 and UBE2N for cancer prevention. 💥🩸על ידי MasterMedFacts LLC
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Lower Blood Pressure, Sharper Minds, Less Dementia, Longer Lives 🧠💊🌾
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3:42🧠 Big win for brains & blood pressure! In a massive rural China trial (n=33,995), lowering BP with non-physician care ↓ dementia risk by 15%! A scalable, lifesaving model for LMICs. 🌾💊📉 #Dementia #Hypertension #GlobalHealthעל ידי MasterMedFacts LLC
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🌬️ Breathe Easy: Nasal Vaccines to the Rescue!
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3:16🚀🌬️ Nasal vaccines: A breath of fresh air in respiratory infection prevention! 🌟 Boosts mucosal immunity (SIgA & IgG) 💪, reduces transmission 🌡️, and protects against COVID-19, influenza, RSV, and more! #Vaccines #PublicHealth #Innovation 🦠💉על ידי MasterMedFacts LLC
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🧬 Silencing Risk: Lepodisiran vs Lp(a)
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4:12🚨 New hope for high Lp(a)! 💉 Lepodisiran, a long-acting siRNA, slashed Lp(a) by 94% with just 2 shots/year. 🔬 RNA precision meets cardiac prevention. 📉 Silent killer, silenced. #CardioTwitter #RNAtherapy #LipoproteinAעל ידי MasterMedFacts LLC
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💨 Breathing Battles: Navigating COPD Phenotypes
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4:15🌬️🚶♂️ COPD comes in many forms! From chronic bronchitis 🪫 to emphysema 💨, frequent exacerbators 🚨, asthma-COPD overlap 🌪️, and eosinophilic type 🧫. Tailoring treatment to phenotype is key! #COPD #PrecisionMedicine #RespiratoryCareעל ידי MasterMedFacts LLC
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💊 TANDEM Triumph: Dual Power for LDL Cholesterol Reduction!
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4:45🚀 TANDEM Trial: Combining Obicetrapib & Ezetimibe for a powerful LDL reduction! 💊 ✅ -48.6% vs placebo, -27.9% vs Ezetimibe, -16.8% vs Obicetrapib 💪 Safe, effective, and oral! #Cardiology #LipidManagement #ASCVDעל ידי MasterMedFacts LLC
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Fungal Pharmacists, Fatty Liver, Future Frontiers 🧬🩸🍄
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4:27A gut fungus 🍄 (Fusarium foetens) secretes FF-C1 🧪, a metabolite that inhibits CerS6 and lowers ceramides 🩸—shielding mice from MASH 🛡️. Fungi aren’t just freeloaders—they may be our next therapeutic allies! 💊🧠 #Microbiome #LiverHealth #FungalTherapy #Scienceעל ידי MasterMedFacts LLC
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💪 Powerful Cholesterol Control: Obicetrapib in the Spotlight 🌟
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2:44🚀 Obicetrapib: A Breakthrough in LDL Lowering! 📉 Reduced LDL by 29.9% in high-risk patients (pעל ידי MasterMedFacts LLC
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Fat Chance! 🔬🧬 Middle-Age Spread Starts at the Cellular Level
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3:13Here’s a tweet with emojis based on the article: 🧬 Middle-age spread decoded! 🕰️ Visceral fat grows in midlife not from bigger cells—but new ones! 🎯 CP-A cells fire up fat formation via LIFR–STAT3 🔥 💊 Targeting them may halt metabolic disease before it starts. #Aging #Obesity #CellBiology #Metabolism 🧫 Would you like a version with a more humorous …
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🔍📊🛡️ Detect, Decode, Defend: A New Era in Coronary Risk Prediction
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3:31🚨 New era in heart disease prediction! 🧬 + 🧪 + 🤖 = Meta-prediction model that beats PCE & QRISK3 📈 Detects hidden CAD risk in young, women & “low-risk” groups 🎯 Precision prevention just got personal. 🫀 Published in Nature Medicine #CardioTwitter #AI #Genomics #CADעל ידי MasterMedFacts LLC
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Dr RR Baliga's Philosophical Discourses: Epicurus (Greece, 341–270 BCE) – Founder of Epicureanism
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3:16Epicurus (341–270 BC) was an ancient Greek philosopher who founded Epicureanism, emphasizing the pursuit of a tranquil, happy life through ataraxia (freedom from fear) and aponia (absence of pain). His teachings combined atomism, ethics, and naturalistic theology, advocating simple living, friendship, and the rejection of superstition.…
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Calcium Wars: Orbital Atherectomy vs. Balloon Angioplasty — The ECLIPSE Verdict ⚔️🧠💔
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3:36🚨ECLIPSE Trial Results🚨 Orbital atherectomy 🌀 vs. balloon angioplasty 🎈 before stenting in severe coronary calcification 💔 🎯 No added benefit with atherectomy 🧠 Balloon-first + imaging = smart strategy 📊 Lancet 2025 | #CardioTwitter #InterventionalCardiology #ECLIPSETrialעל ידי MasterMedFacts LLC
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Genes 🧬, Journeys 🌍, and Hidden Hazards ⚡: Unlocking Health with Exposomics
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2:53“Your DNA 🧬 is just half the story — your exposome 🌍 writes the rest! From air 🌫️ to food 🍎 to stress 😰, exposomics unlocks the hidden drivers of health 🔍💥. Predict. Prevent. Prosper. 🚀 #Exposomics #PrecisionMedicine”על ידי MasterMedFacts LLC
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. 🧩📉 “Unstiff the Heart: Cracking the Code of Cardiac Scars” 🫀🧬
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2:29🫀💊 Scientists found a way to trick heart cells into calming down! Blocking stiffness signals with a smart drug combo reduced scarring and helped hearts pump better in mice. A big step toward #mechanotherapy! 🧠🔬🐭 #CardioTwitter #Fibrosis #HeartHealthעל ידי MasterMedFacts LLC
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“Hope or Hype? Surveillance, Survival, and the Truth About Metastases 🔬⚖️🕯️”
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3:04🧪 Routine scans after cancer treatment: lifesaver or false security? 😰 Evidence shows no survival benefit, but lots of scanxiety, cost, and early toxicity. 💡 Sometimes, less is more. Ask why before you scan. #CancerSurveillance #Oncology 🩺📉על ידי MasterMedFacts LLC
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🕒💔 Heartbeats in Time: How Your Body Clock Protects Your Heart
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3:18⏰🫀 Your heart heals differently depending on the time of day! A protein duo—BMAL1 + HIF2α—peaks in the afternoon, boosting AREG, a heart repair helper. 💔 Morning heart attacks? Worse outcomes. 🕒 Timing meds = better healing. #Chronotherapy #HeartHealth #CircadianScienceעל ידי MasterMedFacts LLC
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🐍 The Man Who Took 200 Snake Bites… and Helped Save Lives!
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2:37🧬💉 Bitten 200+ times, one man’s blood helped create a universal antivenom! 🦸♂️🐍 Human antibodies + varespladib = protection from 19 deadly snake venoms 🛡️🔥 Science just took a big bite out of snakebite! 🌍🔬 #Snakebite #Antivenom #Innovationעל ידי MasterMedFacts LLC
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Running, Risk, and Rescue: Contemporary Insights into Cardiac Arrest in Distance Races
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4:14🏃♂️ Cardiac arrests in marathons stable, but deaths cut in half! 🫀 CAD now the top cause, not HCM. 🚑 Quick CPR + AED saves lives. 📈 Poisson stats confirm the trends! #Running #HeartHealth #MarathonMedicineעל ידי MasterMedFacts LLC
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Brains, Bots, and Balance: Cracking Moravec’s Paradox 🧩🦾🧠
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3:07🤖 Moravec’s Paradox shows that what’s easy for humans—like walking, seeing, or grasping—is hard for AI, while abstract tasks like math or chess are easier for machines. 🧠 Evolution honed our sensorimotor skills over millennia, making them intuitive for us but deeply complex to replicate in code. 🚶♂️ So while AI can solve equations, it still stumbl…
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Lorundrostat’s Promise for Persistent Hypertension
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3:22🚀 Lorundrostat lowers 24-hour systolic BP in resistant hypertension! 🎯 🔬 Selective aldosterone synthase inhibition shows promise but watch for hyperkalemia ⚠️ 🌟 New hope for tough-to-treat BP! #Hypertension #Cardiology #NEJMעל ידי MasterMedFacts.com
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MASH Gets Mashed: Fibrosis Falls, Liver Up, Hopes Rise 💪🧬🚀
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4:06Semaglutide 2.4 mg weekly led to significant resolution of MASH and reduction in fibrosis after 72 weeks 🌟🧬. Patients lost more weight ⚖️, showed better liver markers 📉, and had improved metabolic profiles 💉. GI side effects were common 🤢, but no new safety signals emerged ✅. Promising dual-action therapy for liver and cardiometabolic health! ❤️🩺…
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🥣 Feed. 💪 Heal. 🔄 Recover: Enteral Nutrition in Hospital Care
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3:47🏥 Enteral nutrition is a vital therapy for malnourished hospitalized adults, yet remains underused. 📉 It reduces mortality, readmissions, and complications when oral intake is inadequate. 🧪 Trials show early full feeding may harm in critical illness—underfeeding can be safer. 🧠 Success depends on timing, dose, route, and a team-based, patient-cente…
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Dr RR Baliga's Philosophical Discourses: Mencius (China, c. 372–289 BCE) – Confucian Philosopher
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3:22Mencius (c. 371–289 BC) was a prominent Confucian philosopher known as the “Second Sage” after Confucius. He emphasized the innate goodness of human nature, advocating for humane governance, moral cultivation, and the welfare of citizens. His teachings greatly influenced Confucianism and later Neo-Confucian thought.…
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Mutants, Mitochondria & Metformin 🔬🔋💊: Powering Down Clonal Haematopoiesis
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2:59🧬 Clonal haematopoiesis (CH)—especially with DNMT3A-R882 mutations—increases with age and raises leukemia risk. 💊 New studies reveal that metformin targets mutant blood stem cells by suppressing mitochondrial metabolism, sparing healthy cells. 📉 UK Biobank data shows lower CH prevalence in metformin users. 🔋 Targeting oxidative phosphorylation may …
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A Shot 💉 at Memory 🧠: Can Diabetes Drugs Fight Forgetfulness ❓
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3:10In this large real-world study 🧪 using electronic health records 📊, GLP-1RAs and SGLT2is—two diabetes drugs 💉—were associated with a lower risk of Alzheimer’s and related dementias 🧠 in people with type 2 diabetes 🍬. Both showed protective effects 🛡️, with no significant difference between them, suggesting promise for drug repurposing ♻️ in brain h…
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