Episode 542 - Evolving multicellular life in the lab

Lagrange Point

Its a huge leap from a single celled organism to a complex multicellular beast. So how does evolution manage it? You can evolve humble yeast from a single celled organism into a complex interwoven multicellular one. Over 3,000 generations in the lab, the humble yeast was evolved from microscopic to macroscopic with super strength. Grouping together or splitting apart can offer benefits for organisms, but what environmental pressures cause an organism to go one way or the other?

1. G. Ozan Bozdag, Seyed Alireza Zamani-Dahaj, Thomas C. Day, Penelope C. Kahn, Anthony J. Burnetti, Dung T. Lac, Kai Tong, Peter L. Conlin, Aishwarya H. Balwani, Eva L. Dyer, Peter J. Yunker, William C. Ratcliff. De novo evolution of macroscopic multicellularity. Nature, 2023; DOI: 10.1038/s41586-023-06052-1
2. Florian van der Ent, Susann Skagseth, Bjarte A. Lund, Jaka Sočan, Julia J. Griese, Bjørn O. Brandsdal, Johan Åqvist. Computational design of the temperature optimum of an enzyme reaction. Science Advances, 2023; 9 (26) DOI: 10.1126/sciadv.adi0963