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תוכן מסופק על ידי Peter Attia, MD, Peter Attia, and MD. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Peter Attia, MD, Peter Attia, and MD או שותף פלטפורמת הפודקאסט שלו. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
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#210 - Lp(a) and its impact on heart disease | Benoît Arsenault, Ph.D.

2:07:18
 
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Manage episode 331451207 series 2352826
תוכן מסופק על ידי Peter Attia, MD, Peter Attia, and MD. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Peter Attia, MD, Peter Attia, and MD או שותף פלטפורמת הפודקאסט שלו. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

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Benoît Arsenault is a research scientist focused on understanding how lifestyle and genetic factors contribute to cardiovascular disease risk. In this episode, the discussion casts a spotlight on Lp(a)—the single most important genetically-inherited trait when it comes to atherosclerotic cardiovascular disease (ASCVD) risk. Benoît explains the biology of Lp(a), how it’s inherited, the importance of measuring Lp(a) levels, and the diseases most associated with high Lp(a). He dives into data on the possible treatments for lowering Lp(a) such niacin, statins, and PCSK9 inhibitors, as well as the most exciting new potential therapeutic—antisense oligonucleotides.

We discuss:

  • How Benoît came to study Lp(a)—a new marker for cardiovascular risk [3:15];
  • The relationship between Lp(a) and CVD risk [6:45];
  • What genome-wide association studies (GWAS) revealed about Lp(a) [16:00];
  • Clinical tests to measure Lp(a) [22:00];
  • The biology of Lp(a) [25:45];
  • How statins lower LDL-cholesterol and why this doesn't work for an Lp(a) [29:15];
  • The structure of LDL-p and Lp(a) and what makes Lp(a) more atherogenic than an equivalent LDL particle [34:00];
  • The role of Lp(a) in aortic valve disease [42:45];
  • How greater numbers of Lp(a) particles are associated with increased risk of disease [48:00];
  • The genetics and inheritance of Lp(a) and how and when to measure Lp(a) levels [52:00];
  • Niacin and other proposed therapies to lower Lp(a), apoB, and CVD risk [1:00:45];
  • Why awareness of Lp(a) among physicians remains low despite the importance of managing risk factors for ASCVD [1:14:00];
  • The variability of disease in patients with high Lp(a) [1:19:00];
  • Diseases most associated with high Lp(a) [1:26:30];
  • The biology of PCSK9 protein, familial hypercholesterolemia, and the case for inhibiting PCSK9 [1:35:00];
  • The variability in PCSK9 inhibitors’ ability to lower Lp(a) and why we need more research on individuals with high levels of Lp(a) [1:50:30];
  • Peter’s approach to managing patients with high Lp(a), and Benoît’s personal approach to managing his risk [1:54:45];
  • Antisense oligonucleotides—a potential new therapeutic for Lp(a) [1:57:15]; and
  • More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

  continue reading

348 פרקים

Artwork
iconשתפו
 
Manage episode 331451207 series 2352826
תוכן מסופק על ידי Peter Attia, MD, Peter Attia, and MD. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Peter Attia, MD, Peter Attia, and MD או שותף פלטפורמת הפודקאסט שלו. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.

View the Show Notes Page for This Episode

Become a Member to Receive Exclusive Content

Sign Up to Receive Peter’s Weekly Newsletter

Benoît Arsenault is a research scientist focused on understanding how lifestyle and genetic factors contribute to cardiovascular disease risk. In this episode, the discussion casts a spotlight on Lp(a)—the single most important genetically-inherited trait when it comes to atherosclerotic cardiovascular disease (ASCVD) risk. Benoît explains the biology of Lp(a), how it’s inherited, the importance of measuring Lp(a) levels, and the diseases most associated with high Lp(a). He dives into data on the possible treatments for lowering Lp(a) such niacin, statins, and PCSK9 inhibitors, as well as the most exciting new potential therapeutic—antisense oligonucleotides.

We discuss:

  • How Benoît came to study Lp(a)—a new marker for cardiovascular risk [3:15];
  • The relationship between Lp(a) and CVD risk [6:45];
  • What genome-wide association studies (GWAS) revealed about Lp(a) [16:00];
  • Clinical tests to measure Lp(a) [22:00];
  • The biology of Lp(a) [25:45];
  • How statins lower LDL-cholesterol and why this doesn't work for an Lp(a) [29:15];
  • The structure of LDL-p and Lp(a) and what makes Lp(a) more atherogenic than an equivalent LDL particle [34:00];
  • The role of Lp(a) in aortic valve disease [42:45];
  • How greater numbers of Lp(a) particles are associated with increased risk of disease [48:00];
  • The genetics and inheritance of Lp(a) and how and when to measure Lp(a) levels [52:00];
  • Niacin and other proposed therapies to lower Lp(a), apoB, and CVD risk [1:00:45];
  • Why awareness of Lp(a) among physicians remains low despite the importance of managing risk factors for ASCVD [1:14:00];
  • The variability of disease in patients with high Lp(a) [1:19:00];
  • Diseases most associated with high Lp(a) [1:26:30];
  • The biology of PCSK9 protein, familial hypercholesterolemia, and the case for inhibiting PCSK9 [1:35:00];
  • The variability in PCSK9 inhibitors’ ability to lower Lp(a) and why we need more research on individuals with high levels of Lp(a) [1:50:30];
  • Peter’s approach to managing patients with high Lp(a), and Benoît’s personal approach to managing his risk [1:54:45];
  • Antisense oligonucleotides—a potential new therapeutic for Lp(a) [1:57:15]; and
  • More.

Connect With Peter on Twitter, Instagram, Facebook and YouTube

  continue reading

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