TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.
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This Week in Parasitism


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TWiP 205: Two for the price of one
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The TWiP team solves the case of the Pregnant Ghanian Living Near a River, and reveal emodepside, a drug for treatment of onchocerciasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Download TWiP #205 (56 MB .mp3, 93 minutes) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode …
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This Week in Parasitism


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TWiP 204: Near a fast-flowing river
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The TWiP team solves the case Two Ghanians Near A Fast-Flowing River, and discuss a promising new drug for treatment of African trypanosomiasis. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links for this episode Oral fexinidazole for African trypano…
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This Week in Parasitism


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TWiP 203: True, true, and unrelated
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The TWiP team solves the case of the Shopkeeper with Thirst, Rash, and low Blood Oxygen, then review a study on the effect on survival to adulthood in Tanzania of mosquito net use in early childhood. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Links…
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This Week in Parasitism


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TWiP 202: 80 microns and ovoid
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Sara from the Febrile Podcast joins the TWiP team at The Incubator to solve the case of the Man With an Egg Laden Colonic Mass, and Daniel presents a new puzzle for us to solve. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Guest: Sara Deng Click arrow to play Download TWiP #201 (72 MB .mp3, 60 minutes) Subscrib…
The TWiP team solves the case of the Man with a Cat and Ring Enhancing Lesions, and discuss domestic mammals as reservoirs for Leishmania donovani on the Indian subcontinent. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Reservoirs for …
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This Week in Parasitism


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TWiP 200: Parasites without borders
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The TWiP team solves the case of the Gentleman from New York with Intestinal Issues, and review a 20 year study of butterflies, their associated parasitoid wasp and Wolbachia introduced into an island community. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Download TWiP #200 (41 MB .mp3, 68 minutes) Subscribe (…
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This Week in Parasitism


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TWiP 199: Chagas kisses Cruzi and Brucei bites
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The TWiP team solves the case of the Traveler to Tanzania with a Purple Lesion, and discuss Mosquirix, the first vaccine approved for Plasmodium parasites. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitte…
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This Week in Parasitism


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TWiP 198: Cyclospora in the dining room with the salad bar
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The TWiP quadfecta solves the case of the Traveler With Watery Diarrhea, and reveals that a heat-shock response regulated by a transcription factor protects human malaria parasites from the high temperatures of fever. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Subscribe (free): iTunes, Google Podcasts, RSS, e…
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This Week in Parasitism


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TWiP 197: An adventurous eater
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TWiP solves the case of the Adventurous Eater with Areas of Swelling, and discusses an experimental Trypanosoma vivax vaccine comprising an invariant flagellum antigen. Hosts: Vincent Racaniello, Dickson Despommier, Daniel Griffin, and Christina Naula Download TWiP #197 (39 MB .mp3, 64 minutes) Subscribe (free): iTunes, Google Podcasts, RSS, email …
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TWiP 196: Naked eye entomologist
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TWiP solves the case of the Homeless Man With Skin Issues, and discusses an experimental mRNA based malaria vaccine. Hosts: Vincent Racaniello and Daniel Griffin Download TWiP #196 (49 MB .mp3, 81 minutes) Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter Entomophagy (TWiP 131) Malaria …
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This Week in Parasitism


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TWiP 195: Shocking diseases in attractive NY accents
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Christina returns to the TWiP trifecta to solve the case of the Beachgoer with Red Lines on Her foot, and an experimental malaria vaccine based on the junctional region of the circumsporozoite protein displayed on a virus-like particle. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Christina Naula Download TWiP #195 (46 M…
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This Week in Parasitism


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TWiP 194: Eye had a corneal scraping
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TWiP solves the case of the Long Island Man with Unilateral Eye Pain, followed by a discussion of how enteric helminth coinfection enhances host susceptibility to West Nile virus by a tuft cell-IL-4 receptor signaling axis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Christina Naula Subscribe (free): iTunes, Google Podc…
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This Week in Parasitism


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TWiP 193: A serpiginous trail
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Audun returns to help solve the case of the Ecuadorean Gentleman Treated for COVID-19, followed by a discussion of the interaction of Blastocystis with the intestinal microbiota and the immune system, and of course a new clinical case from Daniel. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Audun Lier Download TWiP #192…
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This Week in Parasitism


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TWiP 192: Towel off vigorously
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The TWiPers solve the case of the Teenager in Malawi with Red Urine, then Audun joins to present our clinical case for this episode. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Audun Lier Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter Hero: George B. Crai…
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This Week in Parasitism


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TWiP 191: Dickson's ocular anomaly
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The TWiPers solve the case of the Rural Man from North Carolina with Blurred Vision, and discuss the results of single-cell RNA sequencing of Schistosoma mansoni. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter RNAseq a…
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This Week in Parasitism


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TWiP 190: But Doc, what could it be?
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Christina from Glasgow returns to help the TWiPlets solve the case of the Ghanian Woman with Abdominal Mass, followed by discussion of the impact of COVID-19 on malaria morbidity and mortality in Africa. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Christina Naula Download TWiP #190 (57 MB .mp3, 94 minutes) Subscribe (fr…
Christina from Glasgow joins the TWiPlets to solve the case of the Elderly Gentlemen with Full Body Rash, and to present a new clinical case for listeners to solve. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Guest: Christina Naula Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, In…
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This Week in Parasitism


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TWiP 188: Terrible tropisms
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Dickson, Daniel and Vincent solve the case of the Baby with Hydrocephalus, and present a new clinical case for listeners to solve. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB on Facebook, Instagram, Twitter Letters read on TWiP 188 Become a patron…
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This Week in Parasitism


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TWiP 187: Granny's granuloma
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Dickson, Daniel and Vincent solve the case of the Middle Aged Woman with Loss of Vision in One Eye, and discuss the role of heme oxygenase in the various protozoan infections. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Heme oxygenase-1 in protozoan i…
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This Week in Parasitism


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TWiP 186: Not rationing rationality
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Dickson, Daniel and Vincent solve the case of the Elder Gardener Feeling Poorly, and discuss the three-dimensional ultrastructure of Plasmodium falciparum during cytokinesis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Three-dimensional structure of m…
Dickson, Daniel and Vincent solve the case of the Wife of a Guy with Cyclospora Diarrhea, and discuss the discovery of an intrinsic oscillator that drives the bloodstream stage cycle of the malaria parasite. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode…
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This Week in Parasitism


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TWiP 184: The hunter gets captured by the game
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Dickson, Daniel and Vincent solve the case of the Safari Goer With Watery Diarrhea, and explain how a microsporidian endosymbiont of Anopheles mosquitoes might impair the transmission of malaria. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Contribute …
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This Week in Parasitism


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TWiP 183: When they dry they die
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Dickson, Daniel and Vincent solve the case of the Female with Itchy Anus, and reveal the structure of a roundworm membrane protein involved in digestion of nutrients. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Structure of roundworm digestive complex…
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This Week in Parasitism


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TWiP 182: Super spreaders of science
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Dickson, Daniel and Vincent solve the case of the Ugandan Volunteer With Morning Bites and discuss integration of HIV-1 into the Schistosome genome, with a sprinkling of COVID-19 throughout. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media…
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This Week in Parasitism


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TWiP 181: Daniel's drive-through
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Dickson, Daniel and Vincent solve the case of the Two Volunteers With Watery Diarrhea, discuss diagnosis of SARS-CoV-2 in the New York area, and reveal an approach to preventing honeybee colony collapse by imbuing their gut bacteria with the ability to produce antiviral and antiparasite double-stranded RNAs. Hosts: Vincent Racaniello, Dickson Despo…
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This Week in Parasitism


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TWiP 180: A spleen palaver
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The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this epis…
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This Week in Parasitism


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TWiP 179: Verminous visitors
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The TWiP DVD solve the case of the Child Who Passed Worms, and discuss a non-human primate model for severe malarial anemia. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Primate model of severe malarial an…
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TWiP 178: The shadowlands of medicine
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The Knights of the TWiP solve the case of the Man Who Lost Weight, and discuss a Plasmodium protein kinase that is a malarial drug target. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode PWB social media: Facebook, Instagram, Twitter Protein kinase as mal…
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This Week in Parasitism


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TWiP 177: A scabrous education
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The TWiPsters solve the case of the Rashy Schoolteacher, and reveal a drug from rotifers that live on the snail intermediate host which paralyzes schistosome cercariae and prevents infection of mice. Hosts: Vincent Racaniello, Dand Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Progress towards global er…
The TWiPpers of the bite fantastic solve the case of the Indian Man Who Hiked, and discuss the effects of schistosome soluble egg antigen on infection of lymphocytes with HIV-1. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Effect of schistosome soluble…
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This Week in Parasitism


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TWiP 175: None alone pathognomonic
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The TWiP'ers solve the case of the Sudanese Boy With Fever, and reveal antibodies against that slow invasion of red blood cells potentiate other malaria-blocking antibodies. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode Antibodies that slow malaria inva…
Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The TWiPloid organisms solve the case of the Doctor with Chronic Epigastric Pain, and reveal how levels of linoleic acid in the intestine enable the sexual cycle of Toxoplasma gondii in cats. Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode: Determinant of…
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TWiP 173: Rose colored spots
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Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species. Subscribe (free): iTunes, Google Podcasts, RSS, email Links for this episode: Matryoshka RNA virus of Plasmodium (bioRxiv) Hero: Rose Gana Fomban Leke Let…
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TWiP 172: A painless lesion
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Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin The metacyclic TWiPomastigotes solve the case of the Child With a Painless Leg Lesion, and reveal how to kill mosquitoes with a genetically modified fungus. Subscribe (free): iTunes, Google Podcasts, RSS, email Transgenic Metarhizium kills mosquitoes (Science) Hero: Veena Tandon Lett…
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TWiP 171: Better than a sharp stick in the eye
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The Leishmaniacs solve the case of the Child With Band Keratopathy, and reveal a eukaryotic parasite with functional mitochondria but without mitochondrial genomes. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Elmer Pfefferkor…
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This Week in Parasitism


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TWiP 170: A worm's eye view
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The TWiPlicates solve the case of the Child With Retinal Granuloma, and discuss an association of the complement protein collectin-11 with the pathophysiology of Chagas disease. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Cha…
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TWiP 169: What goes on in the snail
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The TriTWiPomonads solve the case of the Child Who Passed a Worm, and reveal recombination between bovine and human schistosome species. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: S. bovis and S. haematobiumhybrids (PLoS Pat…
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TWiP 168: Kleptoparasitism and the stercoraceous souvenir
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The Giardians of the Galaxy solve the case of the Woman With a Colonic Stowaway from Hispaniola, and discuss activation of intestinal tuft cells by Trichinella spiralis. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: T. spiralis…
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TWiP 167: The constipated mathematician
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The Tremendous Trio solve the case of the Woman With Foul Steatorrhea, and reveal breakdown of the glycocalyx associated with severe and fatal malaria. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Glycocalyx and severe malaria…
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TWiP 166: From remote locations
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The Podfessors solve the case of the Teenager With Swollen Scrotum, and continue the story arc of Daniel's favorite cells, B-1 cells, and their association with protective immune responses in human Chagas disease. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron …
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TWiP 165: The sound of crackles
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The TWiP team solves the case of the Four Year Old with Fever, Headache, and Cough, and discuss the release of extracellular vesicles from Leishmania amazonensis that manipulate the host immune response. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. L…
The TWiP legends solve the case of Surfer Sans Septum, and discuss how two symbiotic bacteria in the tsetse fly allow colonization with Trypanosoma brucei. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: A Tale of Three Species (…
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TWiP 163: Trout and parasites
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The doctors of awesome solve the case of the Woman Who Visited Lebanon, and reveal that immunoglobulins protect the olfactory organ of trout against infection with the Ich parasite. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode:…
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TWiP 162: That swollen parcel of dropsies
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The TWiP professors solve the case of the Baby With Pericardial Effusion, and discuss whether the flagellate without a flagella, Dientamoeba fragilis, causes human illness. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Patients…
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TWiP 161: All I need is a bit of skin
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The TWiPsters solve the case of the Brazilian Immigrant With Heart Problems, and describe how genome organization controls trypanosome antigenic variation. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Trypanosome genome organi…
The TWiPlets solve the case of the Electrician from Tamil Nadu with a Liver Mass, and reveal that dogs and humans share a common Chadian Guinea worm. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Chadian Guinea worms in humans …
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TWiP 159: Loa and Loa but not gone
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1:35:21
The TWiP triptych solve the case of the 9/11 Survivor infested with parasites, and discuss the effect of community ivermectin treatment for onchocerciasis on Loa loa infections. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiP. Links for this episode: Ive…
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This Week in Parasitism


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TWiP 158: Ant-appetising slime balls
1:22:11
1:22:11
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1:22:11
The TWiP hosts solve the case of the Thai Woman With Red Bumps, and reveal that a master manipulator contacts ant brain tissue to control its behavior. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Imaging parasites in ant brain (Nat Rep) Brain worm turns ants into zombies (Nat Hi…
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This Week in Parasitism


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TWiP 157: What a long, strange TWiP it's been
1:46:01
1:46:01
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1:46:01
The TWiP professors solve the case of the Woman With Intracellular Ring Forms, and explore the role of Coxiella and Rickettsia endosymbionts in acquisition of Babesia by ticks. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Endosymbionts and Babesia in ticks (Front Microbiol) Q fev…
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This Week in Parasitism


1
TWiP 156: The parasitic devil is in the details
1:28:05
1:28:05
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1:28:05
The TWiP crew solves the case of the Ecuadorian with Immunodeficiency and Chronic Diarrhea, and discuss oral transmission of Chagas disease in mice. Hosts: Vincent Racaniello, Dickson Despommier, and Daniel Griffin Become a patron of TWiP. Links for this episode: Imaging Chagas after oral transmission (Sci Rep) NJ invasive species strike team and a…