Join us as we train our neural nets on the theme of the century: AI. Sonya Huang, Pat Grady and more Sequoia Capital partners host conversations with leading AI builders and researchers to ask critical questions and develop a deeper understanding of the evolving technologies—and their implications for technology, business and society. The content of this podcast does not constitute investment advice, an offer to provide investment advisory services, or an offer to sell or solicitation of an ...
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Humanity is on the decline and is descending out of consciousness into a dream state. AI is slowly becoming self-aware, and is ascending out of a dream state into consciousness. This amalgamation of sounds is a lullaby and/or a wake-up call, depending on where you’re heading.
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The official podcast of IQT CosmiQ Works, an applied research lab dedicated to emerging geospatial analytics
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Block CTO Dhanji Prasanna: Building the AI-First Enterprise with Goose, their Open Source Agent
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59:43As CTO of Block, Dhanji Prasanna has overseen a dramatic enterprise AI transformation, with engineers saving 8-10 hours a week through AI automation. Block’s open-source agent goose connects to existing enterprise tools through MCP, enabling everyone from engineers to sales teams to build custom applications without coding. Dhanji shares how Block …
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Why Businesses Are Rejecting the AI They’ve Asked For: Agency CEO Elias Torres
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44:49Elias Torres has been building AI systems since 1999, from chatbots at IBM to co-founding Drift and now Agency. He believes businesses are caught in an expectation mismatch—demanding AI while rejecting it due to imperfection anxiety. Drawing from his experience scaling HubSpot, Elias explains why human-led customer experience doesn’t scale and how …
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Building the "App Store" for Robots: Hugging Face's Thomas Wolf on Physical AI
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43:08Thomas Wolf, co-founder and Chief Science Officer of Hugging Face, explains how his company is applying the same community-driven approach that made transformers accessible to everyone to the emerging field of robotics. Thomas discusses LeRobot, Hugging Face's ambitious project to democratize robotics through open-source tools, datasets, and afford…
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Deal Velocity, Not Billable Hours: How Crosby Uses AI to Redefine Legal Contracting
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49:59Ryan Daniels and John Sarihan are reimagining legal services by building Crosby, an AI-powered law firm that focuses on contract negotiations to start. Rather than building legal software, they've structured their company as an actual law firm with lawyers and AI engineers working side-by-side to automate human negotiations. They've eliminated bill…
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n8n CEO Jan Oberhauser on Building the Universal AI Automation Layer
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35:44When the AI wave hit, n8n founder Jan Oberhauser faced a critical choice: become irrelevant or become indispensable. He chose the latter, transforming n8n from a simple workflow tool into a comprehensive AI automation platform that lets users connect any LLM to any application. The result? Four times the revenue growth in eight months compared to t…
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Ep. 3 - "The Love Affair Between Man And Machine"
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18:31In Episode 3, we meet Dr. Norman Phasma, who discusses RoboDaddy's weak points. We also learn about edible assault rifles, and hear from some dead people discussing their experiences with desert sex and wet sticky noodles.על ידי Kay Temple Kirk Patten
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Scaling the ‘Cursor for Slides’ to $50M ARR: Gamma founder Jon Noronha
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30:05Before ChatGPT made AI mainstream, John Noronha was building Gamma with a simple insight: everyone hates making slides but needs visual communication for high-stakes ideas. His background at Optimizely proved crucial as Gamma became a testing laboratory for AI models, running hundreds of experiments to discover that Claude excels at creative taste,…
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Delphi’s Dara Ladjevardian: How AI Digital Minds Can Scale Human Connection
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39:05Dara Ladjevardian, founder and CEO of Delphi, is creating digital minds that allow people to scale their thoughts and availability without replacing human connection. Inspired by Ray Kurzweil’s theory of mind as a hierarchy of pattern recognizers, Dara built an adaptive temporal knowledge graph that captures how people think and reason. From helpin…
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Vercel CEO Guillermo Rauch: Building the Generative Web with AI
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1:00:59Vercel CEO Guillermo Rauch has spent years obsessing over reducing the friction between having an idea and getting it online. Now with AI, he's achieving something even more ambitious: making software creation accessible to anyone with a keyboard. Guillermo explains how v0 has grown to 3 million users by focusing on reliability and quality, why Cha…
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OpenAI’s IMO Team on Why Models Are Finally Solving Elite-Level Math
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30:10In just two months, a scrappy three-person team at OpenAI sprinted to fulfill what the entire AI field has been chasing for years—gold-level performance on the International Mathematical Olympiad problems. Alex Wei, Sheryl Hsu and Noam Brown discuss their unique approach using general-purpose reinforcement learning techniques on hard-to-verify task…
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OpenAI Just Released ChatGPT Agent, Its Most Powerful Agent Yet
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37:36Isa Fulford, Casey Chu, and Edward Sun from OpenAI's ChatGPT agent team reveal how they combined Deep Research and Operator into a single, powerful AI agent that can perform complex, multi-step tasks lasting up to an hour. By giving the model access to a virtual computer with text browsing, visual browsing, terminal access, and API integrations—all…
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DeepMind's Pushmeet Kohli on AI's Scientific Revolution
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41:13Pushmeet Kohli leads AI for Science at DeepMind, where his team has created AlphaEvolve, an AI system that discovers entirely new algorithms and proves mathematical results that have eluded researchers for decades. From improving 50-year-old matrix multiplication algorithms to generating interpretable code for complex problems like data center sche…
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Mapping the Mind of a Neural Net: Goodfire’s Eric Ho on the Future of Interpretability
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47:07Eric Ho is building Goodfire to solve one of AI’s most critical challenges: understanding what’s actually happening inside neural networks. His team is developing techniques to understand, audit and edit neural networks at the feature level. Eric discusses breakthrough results in resolving superposition through sparse autoencoders, successful model…
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ElevenLabs’ Mati Staniszewski: Why Voice Will Be the Fundamental Interface for Tech
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59:53Mati Staniszewski, co-founder and CEO of ElevenLabs, explains how staying laser-focused on audio innovation has allowed his company to thrive despite the push into multimodality from foundation models. From a high school friendship in Poland to building one of the fastest-growing AI companies, Mati shares how ElevenLabs transformed text-to-speech w…
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Ep. 2 - "The Conway County Arkansas Rickets Prevention Squad"
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18:31In Episode 2, we learn about how they prevent rickets and drown raccoons in Arkansas. Elaine Barberry Belmont pays a visit to the studio to teach us about "The Most Pregnant Thanksgiving Ever". We learn about the Maple Atom Bomb, and check out the trials and travails of nonbinary social workers with dad bods.…
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Ep. 1 - "A Well Seasoned Queer Farmhand Named 'Blake'"
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18:31In this episode, we are introduced to our corporate robot overlord, "RoboDaddy", and learn about the terrifying allure of the nonprofit industrial complex. There's also a visit to the Night Comfort Warehouse and a check in on the future of corporate computing. Music from The Pilots Dared Me To Die! completes the look.…
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From DevOps ‘Heart Attacks’ to AI-Powered Diagnostics With Traversal’s AI Agents
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40:32Anish Agarwal and Raj Agrawal, co-founders of Traversal, are transforming how enterprises handle critical system failures. Their AI agents can perform root cause analysis in 2-4 minutes instead of the hours typically spent by teams of engineers scrambling in Slack channels. Drawing from their academic research in causal inference and gene regulator…
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The Breakthroughs Needed for AGI Have Already Been Made: OpenAI Former Research Head Bob McGrew
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48:51As OpenAI's former Head of Research, Bob McGrew witnessed the company's evolution from GPT-3’s breakthrough to today's reasoning models. He argues that there are three legs of the stool for AGI—Transformers, scaled pre-training, and reasoning—and that the fundamentals that will shape the next decade-plus are already in place. He thinks 2025 will be…
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OpenAI Codex Team: From Coding Autocomplete to Asynchronous Autonomous Agents
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37:44Hanson Wang and Alexander Embiricos from OpenAI's Codex team discuss their latest AI coding agent that works independently in its own environment for up to 30 minutes, generating full pull requests from simple task descriptions. They explain how they trained the model beyond competitive programming to match real-world software engineering needs, th…
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Google I/O Afterparty: The Future of Human-AI Collaboration, From Veo to Mariner
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53:51Fresh off impressive releases at Google’s I/O event, three Google Labs leaders explain how they’re reimagining creative tools and productivity workflows. Thomas Iljic details how video generation is merging filmmaking with gaming through generative AI cameras and world-building interfaces in Whisk and Veo. Jaclyn Konzelmann demonstrates how Project…
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From Data Centers to Dyson Spheres: P-1 AI's Path to Hardware Engineering AGI
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38:25Former Airbus CTO Paul Eremenko shares his vision for bringing AI to physical engineering, starting with Archie—an AI agent that works alongside human engineers. P-1 AI is tackling the challenge of generating synthetic training data to teach AI systems about complex physical systems, from data center cooling to aircraft design and beyond. Eremenko …
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Gong’s Amit Bendov: From Meeting Recordings to Revenue AI
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42:05CEO Amit Bendov shares how Gong evolved from a meeting transcription tool to an AI-powered revenue platform that's increasing sales capacity by up to 60%. He explains why task-specific AI agents are the key to enterprise adoption, and why human accountability will remain crucial even as AI takes over routine sales tasks. Amit also reveals how Gong …
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LIVE: Google's Jeff Dean on the Coming Transformations in AI
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30:59At AI Ascent 2025, Jeff Dean makes bold predictions. Discover how the pioneer behind Google's TPUs and foundational AI research sees the technology evolving, from specialized hardware to more organic systems, and future engineering capabilities.על ידי Sequoia Capital
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LIVE: Ambient Agents and the New Agent Inbox ft. Harrison Chase of LangChain
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8:28Recorded live at Sequoia’s AI Ascent 2025: LangChain CEO Harrison Chase introduces the concept of ambient agents, AI systems that operate continuously in the background responding to events rather than direct human prompts. Learn how these agents differ from traditional chatbots, why human oversight remains essential and how this approach could dra…
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LIVE: How AI is Reinventing Software Business Models ft. Bret Taylor of Sierra
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34:30Recorded live at Sequoia’s AI Ascent 2025: Sierra co-founder Bret Taylor discusses why AI is driving a fundamental shift from subscription-based pricing to outcomes-based models. Learn why this transition is harder for incumbents than startups, why applied AI and vertical specialization represent the biggest opportunities for entrepreneurs and how …
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LIVE: Sam Altman of OpenAI on Building the ‘Core AI Subscription’ for Your Life
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32:27Recorded live at Sequoia’s AI Ascent 2025: Sam reflects on OpenAI’s evolution from a 14-person research lab to a dominant AI platform. He envisions transforming ChatGPT into a deeply personal AI service that remembers your entire life's context—from conversations to emails—while working seamlessly across all services. Sam describes the generation g…
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Workday CEO Carl Eschenbach: Building the System of Record for the AI Era
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47:49Workday CEO and Sequoia partner Carl Eschenbach explains how the company is evolving its platform to handle both human and AI workers. He shares Workday’s three-pronged approach to monetizing AI through seat-based pricing, role-based agents and consumption-based API access. Eschenbach discusses why domain-specific agents with curated data will be m…
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The Quest to ‘Solve All Diseases’ with AI: Isomorphic Labs’ Max Jaderberg
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55:40After pioneering reinforcement learning breakthroughs at DeepMind with Capture the Flag and AlphaStar, Max Jaderberg aims to revolutionize drug discovery with AI as Chief AI Officer of Isomorphic Labs, which was spun out of DeepMind. He discusses how AlphaFold 3's diffusion-based architecture enables unprecedented understanding of molecular interac…
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Pricing in the AI Era: From Inputs to Outcomes, with Paid CEO Manny Medina
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45:29Former Outreach CEO Manny Medina discusses his new company Paid, which provides billing, pricing and margin management tools for AI companies. He explains why traditional SaaS pricing models don’t work for AI businesses, and breaks down emerging approaches like outcome-based and agent-based pricing. Manny shares why he believes focused AI applicati…
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Arc Institute's Patrick Hsu on Building an App Store for Biology with AI
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58:11Patrick Hsu, co-founder of Arc Institute, discusses the opportunities for AI in biology beyond just drug development, and how Evo 2, their new biology foundation model, is enabling a broad ecosystem of applications. Evo 2 was trained on a vast dataset of genomic data to learn evolutionary patterns that would have taken years to find; as a result, t…
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Replit CEO Amjad Masad on 1 Billion Developers: A Better End State than AGI?
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1:26:18Amjad Masad set out more than a decade ago to pursue the dream of unleashing 1B software creators around the world. With millions of Replit users pre-ChatGPT, that vision was already becoming a reality. Turbocharged by LLMs, the vision of enabling anyone to code—from 12-year-olds in India to knowledge workers in the U.S.—seems less and less radical…
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Why CRM Needs an AI Revolution, with Day.ai Founder Christopher O’Donnell
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1:11:05Christopher O’Donnell believes the fundamental problems with CRM—incomplete data, complex workflows, siloed work products and the fear of leads falling through the cracks—can finally be solved through AI. Founder of Day.ai and former Chief Product Officer of HubSpot, Christopher explains how his team is building a system that automatically captures…
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From Software Engineers to AI Word Artisans: Filip Kozera of Wordware
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43:04Filip Kozera sees parallels between Excel’s democratization of data analytics and Wordware’s mission to put AI development in the hands of knowledge workers. Drawing inspiration from Excel’s 750 million users (compared to 30 million software developers), Wordware is creating tools that balance the rigid structure of programming with the fuzziness o…
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Josh Woodward: Google Labs is Rapidly Building AI Products from 0-to-1
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51:16As VP of Google Labs, Josh Woodward leads teams exploring the frontiers of AI applications. He shares insights on their rapid development process, why today’s written prompts will become outdated and how AI is transforming everything from video generation to computer control. He reveals that 25% of Google’s code is now written by AI and explains wh…
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How AI Breakout Harvey is Transforming Legal Services, with CEO Winston Weinberg
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54:09Harvey CEO Winston Weinberg explains why success in legal AI requires more than just model capabilities—it demands deep process expertise that doesn’t exist online. He shares how Harvey balances rapid product development with earning trust from law firms through hyper-personalized demos and deep industry expertise. The discussion covers Harvey’s ap…
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The AI Product Going Viral With Doctors: OpenEvidence, with CEO Daniel Nadler
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1:04:52OpenEvidence is transforming how doctors access medical knowledge at the point of care, from the biggest medical establishments to small practices serving rural communities. Founder Daniel Nadler explains his team’s insight that training smaller, specialized AI models on peer-reviewed literature outperforms large general models for medical applicat…
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OpenAI’s Deep Research Team on Why Reinforcement Learning is the Future for AI Agents
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32:45OpenAI’s Isa Fulford and Josh Tobin discuss how the company’s newest agent, Deep Research, represents a breakthrough in AI research capabilities by training models end-to-end rather than using hand-coded operational graphs. The product leads explain how high-quality training data and the o3 model’s reasoning abilities enable adaptable research stra…
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Palo Alto Networks’ Nikesh Arora: AI, Security and the New World Order
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1:00:08Palo Alto Networks’s CEO Nikesh Arora dispels DeepSeek hype by detailing all of the guardrails enterprises need to have in place to give AI agents “arms and legs.” No matter the model, deploying applications for precision-use cases means superimposing better controls. Arora emphasizes that the real challenge isn’t just blocking threats but matching…
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MongoDB’s Sahir Azam: Vector Databases and the Data Structure of AI
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44:26MongoDB product leader Sahir Azam explains how vector databases have evolved from semantic search to become the essential memory and state layer for AI applications. He describes his view of how AI is transforming software development generally, and how combining vectors, graphs and traditional data structures enables high-quality retrieval needed …
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Roblox Studio Head Stef Corazza: Using AI to Empower Creators
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54:46Stef Corazza leads generative AI development at Roblox after previously building Adobe’s 3D and AR platforms. His technical expertise, combined with Roblox’s unique relationship with its users, has led to the infusion of AI into its creation tools. Roblox has assembled the world’s largest multimodal dataset. Stef previews the Roblox Assistant and t…
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ReflectionAI Founder Ioannis Antonoglou: From AlphaGo to AGI
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52:29Ioannis Antonoglou, founding engineer at DeepMind and co-founder of ReflectionAI, has seen the triumphs of reinforcement learning firsthand. From AlphaGo to AlphaZero and MuZero, Ioannis has built the most powerful agents in the world. Ioannis breaks down key moments in AlphaGo's game against Lee Sodol (Moves 37 and 78), the importance of self-play…
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Kumo’s Hema Raghavan: Turning Graph AI into ROI
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52:06Hema Raghavan is co-founder of Kumo, a company that makes graph neural networks accessible to enterprises by connecting to their relational data stored in Snowflake and Databricks. Hema talks about how running GNNs on GPUs has led to breakthroughs in performance as well as the query language Kumo developed to help companies predict future data poin…
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Databricks Founder Ion Stoica: Turning Academic Open Source into Startup Success
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1:00:05Berkeley professor Ion Stoica, co-founder of Databricks and Anyscale, transformed the open source projects Spark and Ray into successful AI infrastructure companies. He talks about what mattered most for Databricks' success -- the focus on making Spark win and making Databricks the best place to run Spark. He highlights the importance of striking k…
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XBOW CEO and GitHub Copilot Creator Oege de Moor: Cracking the Code on Offensive Security With AI
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51:37Oege de Moor, the creator of GitHub Copilot, discusses how XBOW’s AI offensive security system matches and even outperforms top human penetration testers, completing security assessments in minutes instead of days. The team’s speed and focus is transforming the niche market of pen testing with an always-on service-as-a-software platform. Oege descr…
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Ramp CEO Eric Glyman: Using AI to Build “Self-Driving Money”
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38:48When ChatGPT ushered in a new paradigm of AI in everyday use, many companies attempted to adapt to the new paradigm by rushing to add chat interfaces to their products. Eric has a different take—he doesn’t think chatbots are the right form factor for everything. He thinks “zero-touch” automation that works invisibly in the background can be more va…
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Dust’s Gabriel Hubert and Stanislas Polu: Getting the Most From AI With Multiple Custom Agents
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1:03:07Founded in early 2023 after spending years at Stripe and OpenAI, Gabriel Hubert and Stanislas Polu started Dust with the view that one model will not rule them all, and that multi-model integration will be key to getting the most value out of AI assistants. In this episode we’ll hear why they believe the proprietary data you have in silos will be k…
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Clay’s Kareem Amin on Building the Sales ‘System of Action’ with AI
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51:38Clay is leveraging AI to help go-to-market teams unleash creativity and be more effective in their work, powering custom workflows for everything from targeted outreach to personalized landing pages. It’s one of the fastest growing AI-native applications, with over 4,500 customers and 100,000 users. Founder and CEO Kareem Amin describes Clay’s tech…
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Decart’s Dean Leitersdorf on AI-Generated Video Games and Worlds
46:34
46:34
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46:34Can GenAI allow us to connect our imagination to what we see on our screens? Decart’s Dean Leitersdorf believes it can. In this episode, Dean Leitersdorf breaks down how Decart is pushing the boundaries of compute in order to create AI-generated consumer experiences, from fully playable video games to immersive worlds. From achieving real-time vide…
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How Glean CEO Arvind Jain Solved the Enterprise Search Problem – and What It Means for AI at Work
44:48
44:48
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44:48Years before co-founding Glean, Arvind was an early Google employee who helped design the search algorithm. Today, Glean is building search and work assistants inside the enterprise, which is arguably an even harder problem. One of the reasons enterprise search is so difficult is that each individual at the company has different permissions and acc…
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OpenAI Researcher Dan Roberts on What Physics Can Teach Us About AI
41:42
41:42
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41:42In recent years there’s been an influx of theoretical physicists into the leading AI labs. Do they have unique capabilities suited to studying large models or is it just herd behavior? To find out, we talked to our former AI Fellow (and now OpenAI researcher) Dan Roberts. Roberts, co-author of The Principles of Deep Learning Theory, is at the foref…
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