Can bacteria-free, sterile faecal filtrate match conventional faecal microbiota transplantation for recurrent C difficile infection? Dina Kao unpacks a landmark multicentre trial that tested this hypothesis, and we discuss what it tells us about the role of living organisms in the therapeutic effects of microbiota-based therapies…

Do wheat or gluten trigger IBS symptoms? We spoke to Premysl Bercik about a randomised, double-blind, sham-controlled crossover trial that challenged adults with IBS—who reported benefit from a gluten-free diet—with wheat, gluten, or a gluten-free sham to test symptom and behavioural responses.על ידי The Lancet

Can a multi-metabolite blood test improve early pancreatic cancer detection? We spoke to Julia Mayerle about the METAPAC study, which sought to validate the ability of plasma metabolic signatures to find resectable tumors and reduce unnecessary invasive procedures in high-risk patients.על ידי The Lancet

How does acute kidney injury presentation and management differ globally for patients hospitalised with cirrhosis? We spoke to Salvatore Piano, corresponding author of the landmark International Club of Ascites GLOBAL AKI study, about new data on regional variations in severity, phenotype, treatment, and outcomes across 5 continents.…

John Chia discusses the results of the ASCOLT trial, which explored the effect of aspirin after completion of standard adjuvant therapy for patients with colorectal cancer.על ידי The Lancet

Hannes Hagström discusses a study investigating the feasibility of screening for advanced liver fibrosis alongside retina scanning in people with type 2 diabetes.על ידי The Lancet

Cathy Lu (University of Calgary) discusses a consensus statement on the use of intestinal ultrasound for assessing and monitoring small bowel strictures in Crohn's disease.על ידי The Lancet

Peter De Cruz (University of Melbourne) discusses the PREDICT-UC trial of intensified versus standard dose infliximab induction therapy for steroid-refractory acute severe ulcerative colitis.על ידי The Lancet

Shahida Din (Western General Hospital, Edinburgh) and Beatriz Gros (Reina Sofía University Hospital, Cordoba) discuss two new papers on the harms associated with receiving placebo in induction and maintenance trials of biological therapies and small molecules in inflammatory bowel disease.על ידי The Lancet

Arndt Vogel (Toronto General Hospital) discusses the NALIRICC trial of nanoliposomal irinotecan added to fluorouracil plus leucovorin in patients with cholangiocarcinoma and gallbladder carcinoma previously treated with gemcitabine-based therapies.על ידי The Lancet

Nancy Baxter (University of Melbourne) discusses a population-based study on the duration of risk reduction in colorectal cancer incidence and mortality after a complete colonoscopy.על ידי The Lancet

Sanna Nybacka and Magnus Simrén (University of Gothenburg) discuss the CARIBS randomised controlled trial of a low FODMAP diet versus a low-carbohydrate diet versus pharmacological treatment in IBS.על ידי The Lancet

Nuru Noor (University of Cambridge) discusses the PROFILE trial of biomarker-stratified treatment strategies in people with newly diagnosed Crohn's disease.על ידי The Lancet

Yusuke Shimakawa (Institut Pasteur) discusses the development and evaluation of a simple score for hepatitis B treatment eligibility in Africa.על ידי The Lancet

Mads Israelsen (Odense University Hospital) discusses a study to validate the new nomenclature of steatotic liver disease in patients with a history of excessive alcohol intake.על ידי The Lancet

Louise Dye (University of Leeds) discusses a trial exploring the role of expectancy and gluten ingestion on symptoms in people with non-coeliac gluten sensitivity.על ידי The Lancet

Tzu-Chan Hong (National Taiwan University Cancer Centre) discusses a systematic review and meta-analysis on primary antibiotic resistance of Helicobacter pylori between 1990 and 2022 in the Asia-Pacific region.על ידי The Lancet

Sarah Moen (Erasmus University Medical Center) discusses a retrospective cohort study examining the risk of metachronous colorectal cancer after partial or extensive colectomy in carriers of different pathogenic Lynch syndrome variants.על ידי The Lancet

Anna Emilie Kann (Zealand University Hospital, Denmark) discusses a population-based study done in Denmark exploring the causes of mortality in patients with alcohol-related liver disease.על ידי The Lancet

Robert Krouse (University of Pennsylvania) discusses the pragmatic S1316 trial of surgical versus non-surgical management for patients with malignant small bowel obstruction.על ידי The Lancet

Marc Rothenberg (University of Cincinnati College of Medicine) discusses a new trial assessing the efficacy and safety of benralizumab in patients with eosinophilic gastritis, and how the surprising findings might change our understanding of eosinophilic gastrointestinal diseases.על ידי The Lancet

Michael Pavlides (University of Oxford) discusses work by the LITMUS Consortium on the prognostic performance of non-invasive tests in patients with non-alcoholic fatty liver disease.על ידי The Lancet

Jasmohan Bajaj (Virginia Commonwealth University and Central Virginia Veterans Healthcare System, Richmond, VA, USA), on behalf of the CLEARED Consortium, discusses a prospective observational cohort study examining global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis.…

Adelina Artenie (University of Bristol, UK) discusses a systematic review and meta-analysis exploring the incidence of HIV and HCV among people who inject drugs, and associations with age and sex or gender.על ידי The Lancet

Johan Burisch (Copenhagen University Hospital, Denmark) discusses the findings and recommendations of The Lancet Gastroenterology & Hepatology Commission on the cost of inflammatory bowel disease in high-income settings.על ידי The Lancet

Edouard Louis (University Hospital CHU of Liège) discusses the SPARE randomised controlled trial of infliximab or concomitant immunosuppressant withdrawal in patients with Crohn’s disease.על ידי The Lancet

Paula Ghaneh (University of Liverpool) discusses the ESPAC5 randomised controlled trial of short-course neoadjuvant therapy compared with immediate surgery for patients with borderline resectable pancreatic ductal adenocarcinoma.על ידי The Lancet

Dan Turner (Shaare Zedek Medical Center) discusses the VEDOKIDS study on the safety, effectiveness, and dosing of vedolizumab in children with IBD.על ידי The Lancet

Simon Baunwall (Aarhus University Hospital) discusses the EarlyFMT trial, a randomized placebo-controlled trial of faecal microbiota transplantation for first or second Clostridioides difficile infection.על ידי The Lancet

James Alexander (Imperial College London) discusses the latest findings from the VIP case-control study, which is investigating COVID-19 vaccine immune responses in immunosuppressed patients with inflammatory bowel disease.על ידי The Lancet

Filip Knop (University of Copenhagen) discusses a trial of liraglutide versus colesevelam for the treatment of bile acid diarrhoea.על ידי The Lancet

Edward Kim (Icahn School of Medicine at Mount Sinai) discusses the single-arm RASER study of radiation segmentectomy for patients with unresectable very early to early stage hepatocellular carcinoma.על ידי The Lancet

Joep Ijspeert (Amsterdam University Medical Center) discusses a population-based study exploring the detection of proximal serrated polyps and interval post-colonoscopy colorectal cancer risk.על ידי The Lancet

Elise Meima-van Praag (Amsterdam University Medical Centre) discusses the PISA-II trial, investigating short-term anti-TNF therapy with surgical closure versus anti-TNF therapy for perianal fistulas in Crohn's disease.על ידי The Lancet

Juan Pablo Arab (Catholic University of Chile) discusses the current burden of NAFLD and the landscape of public health policies related to the disease in the Americas.על ידי The Lancet

Sarah Blach (CDA Foundation) summarises the latest analysis of global hepatitis C virus epidemiology and cascade of care by the Polaris Observatory HCV Collaborators.על ידי The Lancet

Sunil Solomon (Johns Hopkins University) discusses a study of a minimal monitoring approach for treating patients with hepatitis C virus infection.על ידי The Lancet

Rupert Leong (University of Sydney) discusses a new double-blind, randomised, placebo-controlled trial of oral faecal microbiota transplantation for patients with active ulcerative colitis.על ידי The Lancet

Swati Patel (University of Colorado Anschutz Medical Center) discusses the epidemiology, clinical features, biology, risk factors, and opportunities for prevention and detection of early-onset colorectal cancers.על ידי The Lancet

Emilie Breekveldt (Erasmus Medical Center, Netherlands) discusses a new analysis of the faecal immunochemical testing-based colorectal screening programme in the Netherlands.על ידי The Lancet

Wendy Spearman (University of Cape Town) discusses a Series on the emergence of non-alcoholic fatty liver disease in Sub-Saharan Africa and the challenges it presents.על ידי The Lancet

Tim Vanuytsel (University of Leuven) discusses a new trial of spore-forming probiotics in functional dyspepsia.על ידי The Lancet

Raymond Henderson (Queen’s University Belfast) discusses a new analysis of the economic burden of colorectal cancer in Europe.על ידי The Lancet

Sigurður Ólafsson (Landspitali University Hospital) discusses newly published results from the nationwide programme to eliminate hepatitis C virus in Iceland.על ידי The Lancet

Caroline Ovadia (King’s College London) discusses an individual participant data meta-analysis on the treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid.על ידי The Lancet

Matthew Akiyama (Montefiore Medical Center and Albert Einstein College of Medicine, USA) discusses a Review on hepatitis C elimination among people incarcerated in prisons.על ידי The Lancet

Monika Sarkar (University of California San Francisco, USA) discusses her Comment on reproductive health in women with chronic liver disease.על ידי The Lancet

Ola Olén discusses the assesment of colorectal cancer risk in patients with Crohn's disease.על ידי The Lancet

על ידי The Lancet

Marc Rothenberg joins The Lancet Gastroenterology & Hepatology to talk about eosinophilic oesophagitis endotype classification.על ידי The Lancet