הפודקאסטים הטובים ביותר ב-T B Determined (2024)

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EP 143: Jordi Ferrer Rendé - Is Healthcare Destroying the Planet? The Shocking Truth About CO2 Emissions 2:05:26

4d ago2:05:26

2:05:26

Artificial intelligence is revolutionizing healthcare, but what if the real danger lies in the industry's carbon footprint? Despite healthcare’s purpose of saving lives, the industry contributes up to 10% of CO2 emissions in developed countries. Can patient care and sustainability go hand in hand, or are we risking the planet's health for human sur…

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A novel tripartite fusion drives treatment resistance in atypical APL; managing iTTP without TPE; hope for motherhood after allogeneic HCT 18:30

5d ago18:30

18:30

In this week's episode we’ll discuss a novel tripartite fusion drives treatment resistance in acute promyelocytic leukemia. In some patients with atypical APL, these novel retinoic acid receptor gene fusions result in truncation of the ligand binding domain of the retinoic acid receptor protein, resulting in non-responsiveness to treatment with all…

1
How to Drive Book Sales Without Offering Discounts 48:13

6d ago48:13

48:13

In this episode, Lauren & Matt explore creative ways to boost book sales! Learn how limited editions, bundles, personalized products, and more can incentivize new and returning shoppers to buy directly from you - without resorting to discounts. Love watching your podcasts? Publish & Prosper is now on video! Check us out on YouTube. Join us at Autho…

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Pirtobrutinib plus venetoclax with or without rituximab in relapsed/refractory CLL; murine models of erythroid 5ALA synthesis disorders; targeting PKCa in diabetes and hemochromatosis 23:17

12d ago23:17

23:17

In this week's episode we’ll discuss the safety and efficacy of pirtobrutinib with or without rituximab in relapsed/refractory CLL; learn more about erythroid 5ALA synthesis disorders and their conditional synthetic lethal dependency on pyridoxine; and discuss how targeting PKC alpha alleviates iron overload in diabetes and hemochromatosis through …

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EP 142: Angeli Moeller - Why AI Isn’t Transforming Healthcare Like It Should 2:10:31

14d ago2:10:31

2:10:31

Artificial intelligence is heralded as the future of healthcare, but why do so many innovations fail to make a tangible impact? Despite the hype, countless companies are missing critical opportunities to leverage AI effectively. What’s holding them back? In this episode, Angeli Möller, CEO of Sequoia Growth, reveals why healthcare AI often falls sh…

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Transplant outcomes in pediatric Fanconi anemia; hepatic Foxo1 regulates iron homeostasis; clinical networks improve APL outcomes in Latin America 18:42

19d ago18:42

18:42

In this week's episode we'll discuss outcomes following hematopoietic stem cell transplantation in pediatric patients with Fanconi anemia. Then, we'll learn about how new research shows that the transcription factor Foxo1, commonly associated with glucose metabolism, regulates hepcidin expression and systemic iron homeostasis. Finally, in Latin Ame…

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EP 141: Alessandro Morra - How AI-Powered Robotics Will Transform Security—Are You Prepared for the Future? 1:50:46

23d ago1:50:46

1:50:46

Many companies today face increasing security challenges, yet few are leveraging the power of AI and robotics to protect their most critical assets. But what if these groundbreaking technologies could not only reduce costs but also provide a more efficient and secure future? In this episode, Alessandro Morra, CEO of Ascento, shares how AI-powered r…

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CD8+ T-cell differentiation and treatment response in AML; ATM germline pathogenic variants affect cancer outcomes in ataxia-telangiectasia; efficacy of a selective menin-KMT2A inhibitor in KMT2A- and ... 22:42

26d ago22:42

22:42

In this week's episode we’ll discuss how CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia; learn more about the effect of ATM germline pathogenic variants on the outcomes in children with ataxia-telangiectasia and hematological malignancies; and discuss the preclinical efficacy of a potent, selective m…

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#140: Customer Obsession Isn’t Enough—What Jeff Bezos Knows That Most Leaders Miss 1:29:50

30d ago1:29:50

1:29:50

What’s the secret to building a trillion-dollar company from scratch? In this episode, we uncover Jeff Bezos' game-changing strategies from Invent and Wander, revealing how Amazon became a global powerhouse. In the world of business and investing, visionary ideas alone are not enough. Invent and Wander reveals that it's a relentless focus on long-t…

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TCR-T cells for post-HCT leukemia recurrence; platelets are the predominant source of procoagulant membranes in hemostasis; BR + R maintenance for MCL 18:10

1M ago18:10

18:10

In this week's episode we'll discuss HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation. Next, we'll learn about how 4D intravital imaging in mice reveals the key role of platelets as a source of procoagulant membranes in hemostasis. Finally, we'll hear about modifications to a common i…

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Outcomes of younger patients with mantle cell lymphoma; M-protein assessment during maintenance therapy in multiple myeloma; in vivo CAR T-cell generation using lentiviral vectors 0:59

1M ago0:59

0:59

In this week's episode we’ll discuss the outcomes of younger patients with mantle cell lymphoma experiencing late relapse; learn more about mass spectrometry-based assessment of M-protein in peripheral blood during maintenance therapy in multiple myeloma and discuss in vivo CAR T-cell generation in non-human primates using lentiviral vectors. Featu…

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Review Series on Factor XI 44:40

1M ago44:40

44:40

Introduced by Associate Editor Dr. Thomas Ortel, this bonus episode discusses the Review Series on Factor XI, published in volume 143 issue 15 of Blood Journal. Dr. Ortel is joined by contributing authors Owen McCarty, PhD, Gili Kenet, MD, and David Gailani, MD. Review Series Articles: Introduction to a review series on factor XI Biology of factor …

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Getting Your Bookstore Ready for the Holidays 51:36

1M ago51:36

51:36

In this episode, Matt & Lauren tackle the upcoming holiday season. They’ll discuss best practices for getting your books ready, optimizing your site or bookstore, speaking to gift givers instead of your target audience, and reviewing your social media for book promo opportunities. Dive Deeper 💡 Check These Resources Make Books Make Bank PDF Downloa…

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EP 139 - Marc Penkala - Why European Startups Must Think Bigger: Lessons from a Top VC on Turning Failure into Fortune 1:59:07

1M ago1:59:07

1:59:07

Many European startups are trapped in a mindset that limits their potential, aiming for millions when they should be thinking in billions. But what if this conservative approach is holding them back from global success? In this episode, Marc Penkala, a leading venture capitalist, reveals the secrets to breaking free from this limiting mindset and h…

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Protective role of neonatal CMV infection in B-ALL; GVHD targets organoid-forming bile duct stem cells; seven-year outcomes for venetoclax-ibrutinib therapy in MCL 16:56

2M ago16:56

16:56

In this week's episode we'll learn how cytomegalovirus infection early in life depletes preleukemic cells in a mouse model of B-cell acute lymphoblastic leukemia. After that we'll discuss new research, where GVHD targets organoid-forming bile duct stem cells in a TGF-beta-dependent manner. Conversely, a TGF-beta inhibitor protects these stem cells …

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Pain Point Solutions for Your Ecommerce Store 45:27

2M ago45:27

45:27

In this episode, Lauren & Matt tackle some common pain points entrepreneurs and ecommerce store owners struggle with. We’ll talk through solutions and tips for collecting sales tax, setting up shipping and managing shipping issues, and providing proactive customer service for your shoppers. Dive Deeper 💡 Sales Tax Lulu Knowledge Base | How Do I Con…

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#138: The PayPal Blueprint: How Vision Without a Business Model Nearly Sunk a Tech Giant 1:16:27

2M ago1:16:27

1:16:27

Ever wondered what it takes to build a tech giant from the ground up? Is it just about having a great idea, or is there a secret formula for success? In this episode, we dive into Jimmy Soni's The Founders, uncovering the key principles that propelled PayPal from a fledgling startup to a cornerstone of the digital economy. In the world of investing…

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Iron, HFE haemochromatosis, and infections; bispecific antibodies improve CAR T-cell response; determinants of outcome in NPM1-mutated AML 23:31

2M ago23:31

23:31

In this week's episode we'll learn about iron, HFE hemochromatosis, and infections. In this large, population-based study, both high and low levels of plasma iron and transferrin saturation were associated with increased risks of infection. Then, we'll discuss how bispecific antibodies improve CAR T-cell response in B-cell malignancies. In-vitro an…

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From Manuscript to Market: 5+ Tools to Help You Draft, Publish, and Sell Your Book 44:42

2M ago44:42

44:42

Self-publishing might be a DIY publishing model, but there are plenty of tools and resources to help you get your book from manuscript to market. In this episode, Matt & Lauren discuss a debatable number of tools to help you draft, edit, format, design, market, and ship your book. Dive Deeper 💡 Learn More About Fictionary Vellum Atticus Bublish Lul…

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Immune fitness and response to taclistamab in R/R multiple myeloma; BCR::ABL1 M244V mutation causes resistance to asciminib; HSCT and myocardial fibrosis in young patients with SCD 16:59

2M ago16:59

16:59

In this week's episode we’ll discuss how immune fitness impacts response to teclistamab in relapsed/refractory multiple myeloma; learn more about a new mechanism of resistance to asciminib conferred by the BCR::ABL1 M244V mutation, and discuss the impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell…

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How to Get Your Book Into Indie Bookstores 41:29

2M ago41:29

41:29

In this episode, Lauren & Matt review strategies for getting your self-published book into indie bookstores, including participating in consignment programs, pitching yourself for author events, and making your book available through retail distribution. Dive Deeper 💡 Read These Blog Posts Selling Your Book on Consignment With Indie Bookstores 5 Vi…

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Decitabine in older patients with AML; EPCR and sickle chronic kidney disease; lymphocyte depletion versus post-transplant cyclophosphamide for mismatched donor transplant for inborn errors of immunity ... 22:53

2M ago22:53

22:53

In this week's episode we’ll discuss the safety and efficacy of decitabine in older patients with AML; learn how heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice, and discuss the outcomes of treatment with HLA-mismatched HSCT with TCRab/CD19 lymphocyte depletion or post-HSCT cyclophosph…

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The Indie Author’s Guide to Self-Publishing vs. Traditional Publishing 50:55

2M ago50:55

50:55

In this episode, Matt and Lauren take listeners on a journey through self-publishing and traditional publishing. We’ll look at where those paths overlap, where they diverge, and what to expect on your publishing adventure. Dive Deeper 💡 Jane Friedman’s The Key Book Publishing Paths 💡 Listen to These Episodes: Episode #2 → Is Self-Publishing the Bes…

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EP 137: Hampus Jakobsson - The Secret to Venture Success: Investing in People, Not Just Ideas 2:12:16

2M ago2:12:16

2:12:16

Did you know the secret to venture success isn't just in groundbreaking ideas? It's in the people behind them. Learn how empathy and grit fuel extraordinary success in this insightful episode. Many investors fail by only chasing ideas. Discover why focusing on the right founders can unlock revolutionary outcomes. Join us as Hampus Jakobsson reveals…

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Impact of MRD-negative on PFS in myeloma; IPSS-R down-staging before transplant in MDS; hereditary angioedema and venous thromboembolism 21:50

2M ago21:50

21:50

In this week's episode we'll discuss minimal residual disease as an intermediate clinical endpoint for multiple myeloma. Then, we'll learn about IPSS-R downstaging before transplant in MDS. Finally we'll hear about the connection between hereditary angioedema and venous thromboembolism. Featured Articles: EVIDENCE meta-analysis: evaluating minimal …

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Designing the Right Go-to-Market Strategy for Your Book 46:30

3M ago46:30

46:30

In this episode, Lauren & Matt dive into what makes a successful go-to-market strategy for your book. Learn how to pick the right launch date and products, choose the best sales and distribution platforms, and craft effective pre-launch and post-launch sales strategies. Have a question about self-publishing, selling direct, Lulu, or any of the weir…

1
Acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; alternative donor transplantation for severe aplastic anemia; clonal relapse dynamics in AML following allogeneic HCT 23:32

3M ago23:32

23:32

In this week's episode we’ll discuss the safety and efficacy of acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; learn more about alternative donor transplantation for severe aplastic anemia and discuss clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation. Featured Articles:…

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Hooking New Readers With a Compelling Book Description 54:34

3M ago54:34

54:34

In this episode, Lauren attempts to convince Matt (and the listeners) of the power of a well-written book description. Listen in to learn how to craft a compelling book description that will help you hook new readers. Have a question about self-publishing, selling direct, Lulu, or any of the weird tangents Matt & Lauren like to meander through? Ema…

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EP 136: Focus and Determination: Lessons from Dan Brisse's Sports and Business Career 1:58:52

3M ago1:58:52

1:58:52

Discover how Dan Brisse, a former X Games gold medalist, transformed his passion for snowboarding into a thriving real estate empire. In this episode of [Podcast Name], we delve deep into Dan's journey, exploring the resilience, focus, and determination that propelled him from professional sports to building Granite Towers Equity Group. 🎙️ What's i…

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Clinical impact of CRh in AML; thrombosis features in a real-life PNH cohort; and restriction of SOX11 expression to EBV-negative Burkitt lymphomas 19:58

3M ago19:58

19:58

In this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants o…

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Books You Can Create Using Your Existing Content 44:20

3M ago44:20

44:20

In this episode, Lauren & Matt share ideas for repurposing your existing content. Hint: it's by turning that content into a book. We share ideas for both nonfiction and fiction book projects, including options that require little to no new writing. Have a question about self-publishing, selling direct, Lulu, or any of the weird tangents Matt & Laur…

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#135: Empowering Innovators: 10 Lessons from The Innovators by Walter Isaacson 1:18:56

3M ago1:18:56

1:18:56

Ever wondered how the digital revolution came to be? Was it the work of lone geniuses, or was there something more at play? In this episode, we delve into Walter Isaacson's "The Innovators," uncovering the collaborative efforts and key principles that have shaped our technological landscape. In the world of investing and entrepreneurship, building …

1
Mutational and transcriptional landscape of pediatric BCP lymphoblastic lymphoma; the role of platelet-derived TGF-1 in immune thrombocytopenia; phase 3 trial of mavorixafor in WHIM syndrome 23:25

3M ago23:25

23:25

In this week's episode we’ll discuss the mutational and transcriptional landscape of pediatric BCP lymphoblastic leukemia; learn more about the role of platelet-derived TGF-β1 in immune thrombocytopenia; and discuss the findings from a phase 3 trial of mavorixafor in WHIM syndrome. Featured Articles: Mutational and transcriptional landscape of pedi…

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5 Things to Know Before You Start Publishing 43:41

3M ago43:41

43:41

In this episode, Matt & Lauren review five things you’ll need to know before you start on your publishing journey! We share insights about knowing your content, knowing your goals, knowing your limits, knowing your audience, and knowing your publisher. Also featuring a meandering detour into graphic novels and an ongoing discussion about crying (no…

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GM-CSF coordinates shelter in the cytokine storm; Interleukin-1 as a therapeutic target in TTP; CAR T-cell outcomes across race and ethnicity in LBCL 19:57

3M ago19:57

19:57

In this week's episode we'll discuss new insights on the role of GM-CSF in establishing immune memory. The authors propose that the coordination of opposing immune memory programs, driven by GM-CSF, may be essential to efficient, yet controlled, innate immune responses. After that: Interleukin-1 inhibition in TTP. Researchers explore the potential …

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Review Series on Oncogenic Signaling and Immune Evasion in Hematologic Malignancies 15:41

3M ago15:41

15:41

Introduced by Associate Editor Robert Zeiser, this Review Series focuses on the problem of immune escape by acute myeloid leukemia (AML). The series opens with a review of how AML escapes T-cell–driven elimination and then focuses on how p53 function impinges on AML recognition by immune cells. The series finishes with a summary of new approaches t…

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Your 7-Step Guide to Building an Online Bookstore 52:34

3M ago52:34

52:34

In this episode Lauren & Matt talk through the 7 essential steps to building your own online bookstore. From choosing the right platform to launching your site, we’ll cover everything you need to know to sell your self-published books directly to your readers. Dive Deeper 💡 Step 1: Shopify Learn More About Selling Your Book With Shopify and Lulu Di…

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EP 134 - The Secret Sauce of California’s Biotech Success Revealed by Joe Panetta 1:03:26

4M ago1:03:26

1:03:26

🚀 Discover the Secret Sauce Behind California’s Biotech Success with Joe Panetta Unlock the keys to California’s biotech boom as we delve into the insights of Joe Panetta, President and CEO of Biocom California. In this episode, we explore the unique factors that have made California a global leader in biotech innovation. Whether you’re a CEO, inve…

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Reassessing the CLL prognostic index; ADAMTS13 conformation and risk of relapse in immune-mediated TTP; haploidentical bone marrow transplant in sickle cell disease 23:39

4M ago23:39

23:39

In this week's episode we’ll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase …

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Finding Your Place in Author & Reader Communities 45:44

4M ago45:44

45:44

In this episode, Matt & Lauren debate the distinctions between author and reader communities, discuss the value of participating in either, and share some suggestions for how to bridge the gap between them. Dive Deeper 💡 Check Out These Online Communities Enter the Luluniverse Meet the Nonfiction Authors Association Learn More About Novelists, Inc.…

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MM 22: Solving Big Problems: Luis Pareras on Smart Investments 6:55

4M ago6:55

6:55

Are you ready to discover the secret behind successful investments? Join us as we delve into the mind of Luis Pareras, a venture capital expert, as he reveals the critical investment principle many founders overlook. 🚀 What if the key to successful investments isn't just about having a solution, but finding the right problem to solve? 🎙️ In this Cl…

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EP 133: Suzanne Heywood - From Shipwreck to Boardroom: How Education Transformed a Life of Adversity into Extraordinary Success 1:53:13

4M ago1:53:13

1:53:13

Imagine spending a decade of your childhood adrift at sea, facing shipwreck and isolation. Could you turn that adversity into a springboard for a remarkable career? Suzanne Heywood, COO of Exor and author of the captivating memoir "Wavewalker," did just that. In this episode, we unpack her incredible journey from a life of hardship to leading a glo…

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A biomarker for disease severity in Wiskott-Aldrich Syndrome; loss of Dnmt3a confers resistance to IFNα; unrelated donor selection in HSCT with PTCy 19:16

4M ago19:16

19:16

In this week's episode we'll discuss assessing risk profile in Wiskott-Aldrich Syndrome, or WAS. Then, we'll learn about how the loss of DNMT3A confers resistance to interferon-alpha in hematopoietic stem cells carrying the JAK2-V617F mutation. Finally, we'll explore unrelated donor selection for AML patients undergoing hematopoietic stem cell tran…

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3 Steps to Prep for an Author Event (and What to Do When You’re There) 48:44

4M ago48:44

48:44

In this episode, Lauren & Matt share their insights from attending dozens of author events to set you up for success. Hear tips for preparing sales strategies and inventory, promoting the event to your fans, and maximizing your presence at the event. Dive Deeper 💡 Learn More About These Events CEX Author Nation NINC 💡 Read These Blog Posts How to P…

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#132: Mastering Risk and Failure: Jeff Bezos' Blueprint for Success (Biography Review) 1:01:14

4M ago1:01:14

1:01:14

Ever wondered how Jeff Bezos transformed a humble online bookstore into the global powerhouse that is Amazon? This biography summary by Influential Individuals uncovers the core principles that propelled Bezos to become the world's richest person. In my martial arts days, a coach taught me to study exceptional role models – a strategy akin to the f…

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Nilotinib with or without cytarabine for Philadelphia-positive AML; thrombosis risk in Factor V Leiden and Prothrombin G20210A; ctDNA improves prognostic prediction in relapsed/refractory multiple myeloma ... 23:05

4M ago23:05

23:05

In this week's episode we’ll discuss the safety and efficacy of nilotinib with or without cytarabine in Philadelphia-positive acute lymphoblastic leukemia; learn more about thrombosis risk in double heterozygous carriers of Factor V Leiden and prothrombin G20210A and discuss the utility of circulating cell-free tumor DNA in prognostic prediction in…

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In the Studio with Author Nation’s Joe Solari 35:17

4M ago35:17

35:17

In this episode, Lauren is joined by Joe Solari, Managing Director of Author Nation, for our first-ever Publish & Prosper interview! Get excited for the Author Nation event coming to Las Vegas this November, take an inside look at CEX 2024, and hear Joe’s thoughts on the future of indie publishing. Dive Deeper 💡 Learn more about Author Nation 💡 Lis…

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EP 131: 🚀 Fast Forward Thinking: Luis Pareras on Future and Science-Driven Innovation 2:17:25

4M ago2:17:25

2:17:25

Unlock the secrets of future-proof investing and transformative innovation in this compelling episode. Join us as we delve into the mind of Luis Pareras, Managing Partner at Invivo Partners, a venture capital fund pioneering investments in cutting-edge biotech. Discover how to navigate the rapidly evolving landscape of science and technology to dri…

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Hemophilia prophylaxis with fitusiran vs BPA/CFC; germline NBN variants in pediatric B-ALL; Histone demethylation and cell-intrinsic immune response in AML 18:59

4M ago18:59

18:59

In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone…

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Determining the Right Retail Price for Your Book 40:55

4M ago40:55

40:55

There’s a fine line to balance when you’re setting the retail price for your book! Too high, and you might discourage potential new readers. Too low, and readers might question the value of your content - or worse, you wind up losing money on every sale. In this episode Matt & Lauren discuss how to determine the optimal list price for your book and…

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פודקאסטים בנושא T B Determined

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