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30. Positive controls in another experiment by Nobel Laureates (mini-series: reading-21)
Manage episode 434677484 series 3493940
תוכן מסופק על ידי Dr. Synaptologica. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Dr. Synaptologica או שותף פלטפורמת הפודקאסט שלהם. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
We will keep analyzing the specific positive controls that the Nobel Laureates used in their milestone article 1 that led to the Nobel Prize. We will examine the four positive controls in the third figure of this paper, and in other figures as well. Those positive controls did not necessarily show positive responses in multiple figures. We will observe that positive controls can show variable behaviors in a paper. We will also discuss how a modified definition of positive controls will be helpful for understanding them.
Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.
- DOI: https://doi.org/10.1016/j.immuni.2005.06.008
- PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf
- PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/
(My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)
54 פרקים
שתפוManage episode 434677484 series 3493940
תוכן מסופק על ידי Dr. Synaptologica. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Dr. Synaptologica או שותף פלטפורמת הפודקאסט שלהם. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
We will keep analyzing the specific positive controls that the Nobel Laureates used in their milestone article 1 that led to the Nobel Prize. We will examine the four positive controls in the third figure of this paper, and in other figures as well. Those positive controls did not necessarily show positive responses in multiple figures. We will observe that positive controls can show variable behaviors in a paper. We will also discuss how a modified definition of positive controls will be helpful for understanding them.
Here are the links to the Milestone Article 1 (Immunity, 2005) by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023.
- DOI: https://doi.org/10.1016/j.immuni.2005.06.008
- PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf
- PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/
(My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)
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Foundational Skills in Life Sciences
1 54. Can you explain the role of Introduction in one sentence? 14:18
14:18 
הפעל מאוחר יותר 
הפעל מאוחר יותר 
רשימות 
לייק 
אהבתי14:18
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיThe single-sentence rule for understanding research paper Introductions. Have you thought about what the Introduction section of a life-science paper really does? In this episode, we will address that question and discuss a simple rule. We will share a single sentence that encapsulates the entire role of the Introduction. It will make it easy to grasp the authors' intention and the paper’s core logic. Hint: it is related to the key trio in the Abstract: the "Background-Known-Unknown" trio from Episode #53. This episode = mini-series: reading-34. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 53. Minimum features of well-written abstracts 16:20
16:20 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי16:20
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיIn today’s episode, we will learn which structural components will be minimally essential for an abstract, and which will be additionally necessary for a well-written abstract. These are the abstracts of primary research papers in life sciences, both in clinical- and basic-science fields. There are very many variations in the structures of published abstracts. Why do we want to discuss the above topic? This is because understanding the essential components of abstracts will help us anticipate key information and understand the content more effectively! This episode = mini-series: reading-33. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 52. Example of a well-written abstract (other than the one by Nobel Laureates) 19:57
19:57 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי19:57
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיLet’s talk about an excellent abstract that I read this week. It was so well written, and I was so excited to read it that I wanted to talk about it with you today. The beauty of it is that the first 3 structural components guide us through the authors’ intention and question very clearly. But there was also a little twist to the structure: we will talk about it, too. The abstract that we talked about today was from the following paper: “A meta-analysis of technology use and cognitive aging” Benge & Scullin, Nature Human Behaviour, 2025 “Online ahead of print” (thus, no volume number or page numbers) as of the date of this episode upload. PubMed link: https://pubmed.ncbi.nlm.nih.gov/40229575/ Journal link: https://doi.org/10.1038/s41562-025-02159-9 We can read its abstract on either of the above websites. Unfortunately, the other parts of the paper are subscription-based. So, they are accessible, if you or your institutions have a subscription to the journal. This episode = mini-series: reading-32. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
My students selected a paper to read in a journal club. The abstract (and the rest of the paper) was not written well. The abstract gave us two precious lessons. Lesson 1: Good structural organization will help the readers understand the content. Lesson 2: Abstracts of peer-reviewed papers can be disorganized. I hope you learn them in this episode, too! This episode = mini-series: reading-31. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
We have reached 50 episodes! Thank you for listening. Today, we will briefly talk about how I have kept sustainable podcasting so far. The most important thing may be that I have set my goal simple and single: It is to create high-quality content for you. That’s it. Here are links to two sources of podcast statistics that I mentioned in the episode. https://www.amplifimedia.com/blogstein-1/lyspqop3ylro9a2t7y2de820uwkgwx https://podcastindex.org/stats (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 49. Another well-crafted logic loop in Abstract by Nobel Laureates (mini-series: reading-30) 18:26
18:26 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי18:26
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיWe will talk about the second of the two, well-crafted loops of logic, in the Abstract of a paper written by the Nobel Prize Laureates. Not all abstracts have this second loop. But when it is present, it gives a better overview of the impact of the presented work. We can find one of the best examples in our Abstract. We are reading the paper written by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman, that led to the Nobel Prize in Physiology or Medicine 2023. We call it the Milestone Article 1. Here are two sets of links related to the paper. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user For finding our Milestone Articles 1, 2 and 3 (i.e., three papers written by the Laureates that led to the Nobel Prize), visit the following website that shows the “Press Release” of the Nobel Prize in Physiology or Medicine 2023. Look for "Key publications" section. https://www.nobelprize.org/prizes/medicine/2023/press-release/ We discussed how to find Milestone Articles 1~3 as above, in Episode #10. Here is the link to the episode: https://synaptologica.buzzsprout.com/2219599/episodes/14122755 (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 48. Well-crafted logic loop in Abstract by Nobel Laureates (mini-series: reading-29) 19:32
19:32 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי19:32
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיI can visualize two well-crafted loops of logic, in the Abstract of a paper written by the Nobel Prize Laureates. Can you? We will talk about one of them in today’s episode. Such a loop, together with a linear progression, highlights the authors’ clear and logical thought process. We are reading the paper written by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman, that led to the Nobel Prize in Physiology or Medicine 2023. We call it the Milestone Article 1. Here are two sets of links related to the paper. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 47. Why is the 2nd sentence important in an abstract? (mini-series: reading-28) 20:32
20:32 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי20:32
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיLet's analyze a single sentence in the Abstract of an impressive paper. It is the paper that led to the 2023 Nobel Prize in Physiology or Medicine. This is the paper that we call the milestone article 1 (Please see below for details). We will analyze the second sentence. Why is this sentence important? We will discuss four of my approaches to see that this sentence is important, beautiful and helpful for readers outside the field. It is fun to spend one episode for just a single sentence, and think deep about how it reveals the authors' logic. Here are two sets of links related to the paper written by the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 46. Let’s analyze the Abstract of a paper written by Nobel Laureates (mini-series: reading-27) 27:59
27:59 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי27:59
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיToday, we will analyze the Abstract of an impressive paper. It is the paper that led to the 2023 Nobel Prize in Physiology or Medicine. This is the paper that we call the milestone article 1. We will have two essential pre-analysis sub-steps, and then we will analyze each sentence. During this analysis, we will read each sentence of the Abstract, examine the role of each sentence, and assign each sentence to a structural component, so that we will be able to understand the authors’ intention for each sentence. Here are two sets of links mentioned in this episode. All are related to the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. Milestone Article 1: “Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA” by Karikó, Buckstein, Ni & Weissman. Immunity, 23(2): 165-75, 2005. DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Copyright of the paper (as of March, 2025): See the pull-down menu “Article Info” near the top of the article webpage (Use the DOI above to reach it). Check the “User License” section which lists the “Elsevier user license”: --- http://www.elsevier.com/open-access/userlicense/1.0/ --- https://www.elsevier.com/about/policies-and-standards/open-access-licenses/elsevier-user (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 45. Let’s read the Abstract of a paper written by Nobel Laureates (mini-series: reading-26) 20:34
20:34 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי20:34
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיToday, we will take a significant step towards understanding the 2023 Nobel Prize in Physiology or Medicine. We will read the Abstract of the Laureates’ most important paper that led to the Nobel Prize. This is the paper that we call the milestone article 1. We will have two essential pre-reading sub-steps, and then we will conduct the initial readings. These sub-steps will set the stage for a more in-depth exploration in the next episode. Here are two sets of links mentioned in this episode. All are related to the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. YouTube video of Nobel announcement (starting at ~2 minutes and 20 seconds) Embedded in Nobel website: https://www.nobelprize.org/prizes/medicine/2023/prize-announcement/ Standalone with time stamp: https://www.youtube.com/watch?v=0JP-yDsLc3k&t=2m20s Milestone Article 1: Immunity, 2005 DOI: https://doi.org/10.1016/j.immuni.2005.06.008 PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 44. An evolving reader: my phases through reading textbooks (Q&A-5: textbooks, part 2) 22:12
22:12 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי22:12
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיHow are you reading life-science textbooks? My approach to reading textbooks has evolved significantly throughout my academic career, from student to researcher to instructor to course director. Today’s episode is part 2. We will discuss the last two phases of my experience. I am now in the fourth phase. I fully appreciate how well the authors summarized a vast amount of knowledge in one field of life sciences, in coherent and consistent manners. Please enjoy listening to my different phases of reading textbooks. It will be great if these episodes serve in stimulating your thoughts about how to read textbooks. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 43. An evolving reader: my phases through reading textbooks (Q&A-5: textbooks, part 1) 22:13
22:13 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי22:13
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיHow are you reading life-science textbooks? My approach to reading textbooks has evolved significantly throughout my academic career, from student to researcher to instructor to course director. Today’s episode is part 1. We will discuss the first two phases of my experience. My overall goal of the two-part episodes is to highlight the unique roles that textbooks play, different from those of primary research papers. Knowing these different purposes will help us read textbooks more effectively. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
Happy Holidays to you, and I wish you the very best in 2025!
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Foundational Skills in Life Sciences
1 41. Exclude or include seemingly irrelevant experiences in your academic CV? (Q&A-4: CV) 22:01
22:01 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי22:01
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי“Should I exclude irrelevant experiences from my academic CV?” This is a question that students often ask. In this episode, I would like to give you my thoughts about this question. In general, there is a way of creating a comprehensive CV: it will show that you have unique experiences, and you are a careful and a thoughtful writer. The key would be for you to be proud of what you did in the past. I hope that this discussion will be useful for you. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 40. Short or long CV for applying for a research position? (Q&A-3: CV) 16:23
16:23 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי16:23
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי“Should my CV be short or long, when I apply for a research assistant position in a college/university lab?” This is a question that students often ask. In this episode, I would like to give you my thoughts about this question. The content in a CV depends on the person’s career stage. But I have one common viewpoint for CVs at all stages. I would like to view the descriptions in the CV, during and after the undergraduate education, as the defining statements of the person. My thoughts about today’s question will be related to this viewpoint. At the same time, I agree that different professors and different students may have opinions different from mine. Let’s discuss them and share diverse perspectives, so that our thoughts will become deeper. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 24. Negative controls put the pieces together in troubleshooting experiments (mini-series: reading-16) 46:41
46:41 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי46:41
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיWe will see how the experimenters implemented a good, troubleshooting idea into a protocol that appeared to be challenging at first. We are continuing to discuss the troubleshooting of a real, life-science experiment in our story. Sophisticated thought processes made the experiment possible in the end. This episode celebrates the power of well-designed experiments. We'll see how meticulous planning and a systematic approach to troubleshooting can overcome seemingly insurmountable obstacles. This is Part 16 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active: ideas@synaptologica.com. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 23. Refining a troubleshooting idea: the power of identifying unknowns (mini-series: reading-15) 25:11
25:11 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי25:11
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיWe will discuss the fourth and final idea, for troubleshooting a real, life-science experiment in our story. This idea was based on the previous three ideas. Then the experimenters took an impressive step. They identified key unknowns about the experiment, and refined and updated their idea. The updated idea laid the foundation for designing the crucial, fourth and final troubleshooting experiment that we will discuss in the next episode. This is Part 15 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active: ideas@synaptologica.com. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 22. Negative controls unveil a hidden culprit in a problematic experiment (mini-series: reading-14) 14:39
14:39 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי14:39
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיWe continue our deep exploration into negative controls and their importance in troubleshooting life-science experiments. We follow a real-life story of an experiment that yielded unexpected results. Through the third troubleshooting experiment utilizing negative controls, the experimenters finally uncovered the culprit. We discuss how negative controls helped identify the problem and pave the way for further investigation. This is Part 14 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
We will be happy to announce the launch of a new way to stay connected with the show - a FREE email newsletter! Sign up to get updates on upcoming episodes, behind-the-scenes insights, and more. Please join the community by sending an email to: ideas@synaptologica.com. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 20. Detective work of troubleshooting a puzzling experiment: negative control as a guide (mini-series: reading-13) 23:20
23:20 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי23:20
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיWe will experience the fascinating world of scientific troubleshooting. In this episode, we will revisit a life-science experiment where researchers aimed to see if a specific chemical compound could enhance a particular function in cultured cells. Their plan seemed straightforward - a pilot experiment with a positive control (active compound) and a negative control (inactive compound). They wanted to confirm everything worked as expected. But the results were strange! Both the positive and negative controls showed unexpectedly high cell function, leaving the researchers scratching their heads. Join us as we explore the initial troubleshooting steps. Help us by showing your idea: where in the protocol the problem could be hiding. Stay tuned for the next episode where we continue this exciting discussion. This is Part 13 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 19. Negative controls are important: a story (mini-series: reading-12) 12:07
12:07 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי12:07
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיThere are many reasons why life-science experiments do not work well. Today, I will tell you a real story about an experiment. It is an experiment that did not go well. We will explore the problem that researchers encountered. In the following episodes), we will discuss how they identified the problem, and how they solved the problem. The story will help us understand the importance of negative controls, especially how to design them for the experiments, and how to use them for trouble-shooting problematic experiments. This is Part 12 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 18. In-depth analysis of negative controls: using Nobel Laureates’ as example (mini-series: reading-11) 30:11
30:11 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי30:11
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיToday's focus: negative controls. In life-science experiments, negative controls play critical roles. In my view, they are more important than the positive controls! They form such a rich topic that we will spend at least a few episodes on discussing them. Today, we introduce basic aspects: 1) what the negative controls do in life-science experiments, 2) our practical definition by modifying the typical and ideal one, 3) how the negative control was used in our milestone graph (Fig. 3D of milestone article 1 by the Laureates of the Nobel Prize in Physiology or Medicine 2023), and 4) two critical assumptions for negative controls to work properly. This is Part 11 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 17. Links to 3 milestone articles & YouTube video presentation: Nobel Prize for Physiology or Medicine 2023 (mini-series: reading-10) 6:01
I will list four sets of links mentioned in this episode. All are related to the Laureates, Dr. Katalin Karikó & Dr. Drew Weissman of the Nobel Prize in Physiology or Medicine 2023. Milestone Article 1: Immunity, 2005 - DOI: https://doi.org/10.1016/j.immuni.2005.06.008 - PDF: https://www.cell.com/immunity/pdf/S1074-7613(05)00211-6.pdf - PubMed: https://pubmed.ncbi.nlm.nih.gov/16111635/ Milestone Article 2: Molecular Therapy, 2008 - DOI: https://doi.org/10.1038/mt.2008.200 - PDF: https://www.cell.com/action/showPdf?pii=S1525-0016%2816%2932681-8 - PubMed: https://pubmed.ncbi.nlm.nih.gov/18797453/ Milestone Article 3: Nucleic Acids Research, 2010 - DOI: https://doi.org/10.1093/nar/gkq347 - PDF: https://academic.oup.com/nar/article-pdf/38/17/5884/16767310/gkq347.pdf - PubMed: https://pubmed.ncbi.nlm.nih.gov/20457754/ YouTube video of Nobel announcement - Embedded in Nobel website: https://www.nobelprize.org/prizes/medicine/2023/prize-announcement/ - Standalone with time stamp: https://www.youtube.com/watch?v=0JP-yDsLc3k&t=2m20s Enjoy and let's learn from them! This is Part 10 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 16. Graph axis labels by Nobel Laureates: the secret method of scientific communication (mini-series: reading-9) 28:58
28:58 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי28:58
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיToday's focus: the power of text elements in figures. We explore how category axis labels in bar graphs, when meticulously organized, reveal key experimental conditions at a glance. For a prime example, take Fig. 2B from our milestone article 1 by the Laureates of the Nobel Prize in Physiology or Medicine 2023. Here, the labels use two key strategies: 1) precise keywords accurately represent each condition, and 2) a three-layered structure visually communicates relationships between conditions. The next time you encounter a graph, take a moment to appreciate the labels and how they efficiently convey information. This is Part 9 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 15. Let's read a bar graph made by Nobel Laureates (mini-series: reading-8) 22:42
22:42 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי22:42
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיDive deep into Step 11 of reading the milestone article written by Nobel Laureates. We will examine the most important bar graph. We will read the labels and the legend, and combine our knowledge with the Nobel Committee video. We will use the information flexibly to understand the story the graph tells. This is Part 8 of the reading mini-series "Let’s read a paper written by Nobel Prize Laureates, 2023." (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 14. Let’s read a paper written by Nobel Prize Laureates, 2023: Part 7 (mini-series: reading-7) 17:00
17:00 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי17:00
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיVisual elements in scientific papers often convey information faster than words. In Part 7 of reading mini-series, we will discuss previewing the paper content by scanning the figures and tables. This step will help us gain a quick overview of Nobel Prize-winning research. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 13. Let’s read a paper written by Nobel Prize Laureates, 2023: Part 6 (mini-series: reading-6) 14:06
14:06 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי14:06
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיIn Part 6 of reading mini-series, we will discuss key steps before diving into a paper. We will verify the paper's identity and map its structure. These simple actions will give us a bird's-eye view of the paper and set us up for a deeper, rewarding reading experience. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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Foundational Skills in Life Sciences
1 12. Let’s read a paper written by Nobel Prize Laureates, 2023: Part 5 (mini-series: reading-5) 15:12
15:12 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי15:12
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיWelcome to Part 5 of our mini-series on reading. Today, we will discuss a crucial step before diving into a paper. This powerful step will shift your focus from passively absorbing the written content to actively engaging with the authors' intent. By understanding what they are doing with each sentence and paragraph, you will gain a clearer overview of the paper's meaning. So, what is this important step? (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
Thank you for listening. I started podcasting earlier in 2023. The total number of episode downloads reached 250 on the day of this recording. Please keep listening to the episodes to come!
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Foundational Skills in Life Sciences
1 10. Let’s read a paper written by Nobel Prize Laureates, 2023: Part 4 (mini-series: reading-4) 18:16
18:16 הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתי18:16
הפעל מאוחר יותר הפעל מאוחר יותר רשימות לייק אהבתיThis episode is Part 4 of a multi-episode mini-series on reading. When we want to read a paper written by the Nobel Laureates, you might wonder which one to choose. We will discuss how to select the right paper from among the many that the Laureates have written. How do we do it? There's a simple way. (My email is active. But my website is under construction. Please wait for a while. Thank you for the patience!)…
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