Episode 524 - Bacteria’s sneaky 1-2 punch to get into your brain

Lagrange Point

Bacteria uses a clever 1-2 punch to make it through our central nervous systems defenses. The way bacteria can get through the outer layers of the meninges relies on knowing exactly what how the brain will respond to infection. Painful headaches are a key part of meningitis, but that pain response is actually opening the door for a sneak attack. Understanding how bacterial infections get into the brain will help develop new treatment pathways for meningitis. When bacteria come under attack themselves, they use signalling pathways that we can learn from. By studying the way bacteria defend themselves we could find common tools to use to precisely regulate human cells.

1. Felipe A. Pinho-Ribeiro, Liwen Deng, Dylan V. Neel, Ozge Erdogan, Himanish Basu, Daping Yang, Samantha Choi, Alec J. Walker, Simone Carneiro-Nascimento, Kathleen He, Glendon Wu, Beth Stevens, Kelly S. Doran, Dan Levy, Isaac M. Chiu. Bacteria hijack a meningeal neuroimmune axis to facilitate brain invasion. Nature, 2023; DOI: 10.1038/s41586-023-05753-x
2. Hannah E. Ledvina, Qiaozhen Ye, Yajie Gu, Ashley E. Sullivan, Yun Quan, Rebecca K. Lau, Huilin Zhou, Kevin D. Corbett, Aaron T. Whiteley. An E1–E2 fusion protein primes antiviral immune signalling in bacteria. Nature, 2023; DOI: 10.1038/s41586-022-05647-4