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Ep. 14–Brian Fiske & Jeff Kelly: Accelerating Discoveries to Treat Neurodegenerative Disease

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Manage episode 394318144 series 1908208
תוכן מסופק על ידי Science Changing Life and Scripps Research. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Science Changing Life and Scripps Research או שותף פלטפורמת הפודקאסט שלהם. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
Dr. Brian Fiske is the Senior Vice President for Research Programs at the Michael J. Fox Foundation for Parkinson’s Disease. Professor Jeff Kelly is in the Department of Chemistry at Scripps Research. Listen as we talk about biomarkers for early disease detection, the importance of long-term human trials, and how Parkinson’s disease could originate in the gut. Show notes: Dr. Fiske’s bio at MJFF https://www.michaeljfox.org/foundation/leaders.html?subcatid=381 Prof. Kelly’s bio at Scripps Research https://www.scripps.edu/faculty/kelly/ Coverage of FDA approval of Tafamidis https://www.scripps.edu/news-and-events/press-room/2019/20190506-fda-approved-tafamidis.html https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatments-heart-disease-caused-serious-rare-disease-transthyretin-mediated Social Media: Twitter/Instagram: @MichaelJFoxOrg Remember to follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn
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52 פרקים

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iconשתפו
 
Manage episode 394318144 series 1908208
תוכן מסופק על ידי Science Changing Life and Scripps Research. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Science Changing Life and Scripps Research או שותף פלטפורמת הפודקאסט שלהם. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
Dr. Brian Fiske is the Senior Vice President for Research Programs at the Michael J. Fox Foundation for Parkinson’s Disease. Professor Jeff Kelly is in the Department of Chemistry at Scripps Research. Listen as we talk about biomarkers for early disease detection, the importance of long-term human trials, and how Parkinson’s disease could originate in the gut. Show notes: Dr. Fiske’s bio at MJFF https://www.michaeljfox.org/foundation/leaders.html?subcatid=381 Prof. Kelly’s bio at Scripps Research https://www.scripps.edu/faculty/kelly/ Coverage of FDA approval of Tafamidis https://www.scripps.edu/news-and-events/press-room/2019/20190506-fda-approved-tafamidis.html https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatments-heart-disease-caused-serious-rare-disease-transthyretin-mediated Social Media: Twitter/Instagram: @MichaelJFoxOrg Remember to follow @ScrippsResearch on Twitter, Instagram, Facebook and LinkedIn
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Long COVID affects millions of people worldwide, yet many questions about the condition remain unanswered. In this episode of Science Changing Life, Julia Moore Vogel, PhD, shares what it’s like to study—and live with—long COVID. As the senior director of the All of Us Research Program, Julia discusses how her experience has fueled innovative research to improve symptom management and health equity for patients with the condition. Listen in to learn how Julia transforms personal challenges into professional breakthroughs. Twitter: https://x.com/julialmv LinkedIn: https://www.linkedin.com/in/juliamoorevogel All of Us Research Program: https://www.joinallofus.org/ Scripps Research Magazine: magazine.scripps.edu/…
 
In the second part of our conversation with Dr. Eric Topol, we explore how examining the past is necessary to ensure we’re more prepared for our future. From universal vaccines and advanced antiviral therapies to cutting-edge digital tools like wearable biosensors and genomic surveillance, Dr. Topol shares actionable insights on harnessing technology and data to revolutionize pandemic preparedness. Listen in as we discuss the path to a safer, healthier future. // Episode transcript: https://www.scripps.edu/_files/images/2024_images/topol-pandemic-prep-transcript.pdf Twitter: https://twitter.com/EricTopol LinkedIn: https://www.linkedin.com/in/eric-topol-md-b83a7317/ Ground Truths podcast: erictopol.substack.com Scripps Research Magazine: magazine.scripps.edu/…
 
Artificial intelligence is revolutionizing what we once thought impossible. But how can we distinguish genuine breakthroughs from mere hype? In this episode of Science Changing Life, we welcome Eric Topol, MD—renowned physician, scientist, and author. As executive vice president at Scripps Research and founder of the Scripps Research Translational Institute, Dr. Topol shares his thoughts on how AI is transforming science and medicine today and offers a glimpse into what the future may hold. His advice to listeners? 'Be open to change.' Twitter: https://twitter.com/EricTopol LinkedIn: https://www.linkedin.com/in/eric-topol-md-b83a7317/ Ground Truths podcast: erictopol.substack.com Scripps Research Magazine: magazine.scripps.edu/…
 
Thanks to revolutionary technologies like CRISPR, we’re now living in an age where it’s becoming possible to rewrite the very building blocks of life itself—our DNA. We sit down with Scripps Research Fellow and CRISPR expert Shannon Miller, PhD, to discover how these gene editing technologies are poised to reverse a range of diseases. Listen in as we explore Shannon’s unique journey into science—beginning not with a single eureka moment, but instead with a passion for creativity and discovery. Twitter: https://twitter.com/_shannonmmiller Miller lab: https://www.millerlabresearch.com/team Scripps Research Magazine: https://magazine.scripps.edu/…
 
Four years after the onset of the COVID-19 pandemic, another virus threatens to reach pandemic potential: the H5N1 bird flu. We sit down with Arnab Chatterjee, vice president of medicinal chemistry at Calibr-Skaggs, who explains the need to invest in the best science to make sure we’re more prepared than we were for the SARS-CoV-2 outbreak. Chatterjee breaks down how likely it is for H5N1 to become transmitted between humans, and the steps we can take now to better protect ourselves in the future. LinkedIn: linkedin.com/in/arnab-chatterjee-b024661/ Scripps Research Magazine: magazine.scripps.edu/…
 
Galileo’s telescope revolutionized our modern understanding of the universe. Assistant neuroscience professor Xin Jin, PhD, wants to do just that—except for the brain. By building new tools that enable her and other neuroscientists to peer into the inner workings of the mind, Jin is uncovering the cells, genes and other complex drivers behind neurological diseases. Listen in as we explore the galaxy of the brain. Twitter: https://x.com/xinjin Jin lab: https://www.jin.scripps.edu/ Scripps Research Magazine: magazine.scripps.edu/…
 
More than 90% of drugs fail to make it from the lab bench to approval. How, then, has a physician-scientist like Hugh Rosen found so much success in developing medicines? Rosen, who’s the chair of molecular and cellular biology at Scripps Research, co-invented the drugs ozanimod (approved for multiple sclerosis and ulcerative colitis) and navacaprant (in Phase 3 trials for major depressive disorder). In this episode of Science Changing Life, listen in as Rosen unveils the success stories behind these groundbreaking treatments—shedding light on the challenges and triumphs shaping modern medicine. Rosen Lab: https://www.scripps.edu/rosen/index.html Scripps Research Magazine: magazine.scripps.edu/…
 
Donna Blackmond never thought her career would lead to solving how life first formed on the prebiotic Earth. But as she points out in this episode of Science Changing Life, does any scientist start out knowing where their research will take them? Blackmond, who is a professor and the John C. Martin Endowed Chair in Chemistry at Scripps Research, shares how her wide-ranging background across chemistry and chemical engineering is helping answer some of today’s biggest questions in science and medicine. Episode transcript: https://www.scripps.edu/_files/images/2024_images/donna-blackmond-podcast-episode-45-transcript.pdf Blackmond Lab: https://www.scripps.edu/blackmond/ Blackmond’s recent PNAS and Nature papers: https://www.scripps.edu/news-and-events/press-room/2024/20240228-blackmond-molecules.html Scripps Research centennial: 100.scripps.edu/ Scripps Research Magazine: magazine.scripps.edu/…
 
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Ahmed Badran is an assistant professor of chemistry at Scripps Research, where his lab harnesses synthetic biology to address some of biggest global problems. Listen in as we discuss reengineering plant enzymes to capture carbon, plastic-eating bacteria and new classes of antibiotics that spare our gut microbiome. Episode transcript: https://www.scripps.edu/_files/images/2023_images/ahmed-badran-transcript.pdf Badran lab website https://badranlab.com/ Twitter @AhmedHBadran Scripps Research Magazine https://magazine.scripps.edu/…
 
Professor Mia Huang is based in the Department of Molecular Medicine at Scripps Research, where her lab explores how vital sugar molecules in the body orchestrate complex biological events. Listen in as we discuss deciphering cancer cell signals to develop new therapies, engineering red blood cells for transfusions and how to become a master of strategy. Episode transcript: https://www.scripps.edu/_files/images/2023_images/mia-huang-transcript.pdf Huang lab website https://www.huangresearch.com/ Q&A with Mia https://magazine.scripps.edu/profiles/2020/fall/science-with-a-view-understanding-how-natures-biomolecules-tick-with-mia-huang/ Twitter @HuangMia Scripps Research Magazine https://magazine.scripps.edu/…
 
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Professor Sumit Chanda is an infectious disease expert and immunologist, where he works both in the Department of Immunology and Microbiology and at Calibr, Scripps Research’s nonprofit drug discovery and development division. He has devoted his career to understanding how the immune system responds to numerous viruses, such as influenza, Dengue virus and SARS-CoV-2. Listen as we discuss everything from pandemic preparedness to drug discovery, as well as his unrelenting drive to uncover new treatment options—including for COVID-19. Episode transcript https://www.scripps.edu/_files/images/2023_images/sumit-chanda-transcript.pdf Infectious disease sleuth Sumit Chanda, PhD, joins Scripps Research and its Calibr drug discovery division https://www.scripps.edu/news-and-events/press-room/2021/20210915-chanda-calibr.html Center for Antiviral Medicines & Pandemic Preparedness https://www.campp.org/ Chanda lab website https://linktr.ee/thechandalab Twitter/Instagram @thechandalab…
 
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Are the mitochondria truly the powerhouses of the cell? In this episode, assistant professor Danielle Grotjahn shares why she thinks “the stress sensors of the cell” may be a more appropriate name for this cellular organelle–and more. Dr. Grotjahn works in the Department of Integrative Structural and Computational Biology at Scripps Research, where her lab is answering how mitochondrial networks change shape in response to genetic, pharmacological or environmental stress. Listen as we talk about the links between mitochondrial dysfunction and disease, cell death, and the cutting-edge imaging technologies that are enabling Grotjahn and her team to peer into the mysteries of the mitochondria. Show notes: Episode transcript: https://www.scripps.edu/_files/images/2023_images/danielle-grotjahn-transcript.pdf Grotjahn lab website https://grotjahnlab.org/ Twitter @nani_grotjahn Scripps Research Magazine https://magazine.scripps.edu/…
 
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