#001 Dr Jin Xiong She - Exploring NAD+ and Cellular Energy

vP life

vitalityPRO

#001 Dr Jin Xiong She - Exploring NAD+ and Cellular Energy

Dr. Jin-Xiong She received his college education in China and PhD degree in France. He served as Division Chief of Experimental Pathology and Director of Research of the UF’s world-class Diabetes Centre. In his long academic career, Dr She has authored over 400-peer peer-reviewed papers with an H-Index of 76 and over 19,000 citations, secured over $100 million in research grants and has been invited to speak globally. Dr. She is one of the 20 “Georgia Top Medical Researchers”. He served as President of the Chinese Geneticists in America and President of the American Diabetes Association’s Council on Immunology, transplantation and Immunogenetics among other honours. Dr. She is a serial entrepreneur and has founded multiple companies in the US and China. Currently, Dr She oversees operations as CEO of Jinfiniti Precision Medicine, a company dedicated to optimising healthspan through advanced biomarker testing and precision supplementation.

Guest Introduction [00:00:38]

> Who Dr She is and what his background is.

Jinfiniti Precision Medicine [00:01:21]

> How and why Dr She started Jinfiniti Precision Medicine.

Longevity [00:02:22]

> How Dr She defines longevity and what his approach is to enhancing both health span and longevity

> What are the biggest needle movers for longevity

> Diet

> Inflammation

> Glycemic Variability

> Epigenetic Role of Stress

> Upregulation cytokines, NF-KB, other transcription factors etc as a result of

> Exercise

General conversation points

> What are Dr She’s thoughts on NR and NMN and why does he prefer NMN [00:25:11]

> Why Niacin may not be the optimal NAD precursor [00:29:53]

> High-dose niacin insulin resistance

> N1-methyl-2-pyridone-5-carboxamide (2PY) and N1-methyl-4-pyridone-3-carboxamide (4PY)

> You can only treat what you can test, we have tests for markers of inflammation but up until now not a direct marker for senescence.

> Senescence-associated β-galactosidase (SABG or β-gal)

> Discussion around Accuri, Dr She’s NAD boosting formula [00:43:51]

> D RIbose for Ribose Base of NMN

> Creatine - ATP synthesis

> Age tests [00:55:14]

> What they are and are they worth it

> Clinical endpoints

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• Nature Medicine - A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk - Mentioned in the She podcast, this study examines high dose niacin and it's negative effects.