Health Discourse with Sakshi & Sushant- Episode 2

Genefitletics

Solving & finding the underlying cause why people develop metabolic disease trilogy- Type 2 diabetes-Cardiovascular Diseases- Chronic Kidney Disease has been a nightmare. More so as our modern healthcare system, treat all three diseases separately & treat separate organs. What if all these three diseases are connected? Why are our healthcare professionals missing out on this? Why we just end up managing these diseases which becomes more dangerous given the fact that they are silent killers With 10% of the Indian population dealing with CKD, cardiovascular disease number one killer & 100 million people dealing with diabetes, why do we not have a solution? Can we just manage them through pharmaceutical interventions, tracking plasma level markers through blood works, fad diets, & endless dialysis sessions? What if it roots from the most neglected organs- Gut & Oral microbiome? As year 2023 comes to close , we decode the interconnection between these 3 diseases & how oral & gut microbial sub optimal functions triggers onset & progression of type 2 diabetes, Chronic Kidney Disease & Cardiovascular disease. While you could listen to this exciting conversation, summary of few molecular signals involved in develop of these diseases - Low Nitric Oxide production caused by inflammation, oxidative stress, decreased transport of L-arginine to endothelial cells, increased circulatory level of NO inhibitor- ADMA & oxidation of NOS cofactor tetrahydrobiopterin -Competition between NOS & Arginase for L-arginine in case of excess L-arginine supplementation which makes Arginase trigger oxidative stress. -Elevated TMAO, LPS, p-Cresol & Indoxyl Sulphate levels released by gut microbiome & more,

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