הפודקאסטים הטובים ביותר ב-Orlando And Nicole (2024)

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EP 149: Sequencing 33 million samples to support the UK’s COVID-19 response with Tony Cox, CEO of UK Biocentre 34:16

7h ago34:16

34:16

0:00 Intro to The Genetics Podcast 01:00 Welcome to Tony 02:00 What Tony was expecting going into the role of CEO at UK Biocentre, and how the COVID-19 pandemic changed his plans 03:38 Receiving a phone call from the UK government in March 2020 asking the UK Biocentre to stop all of its projects and focus on sequencing COVID-19 samples 05:12 The UK…

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EP 148: Advancing veteran health through the Million Veteran Program with Dr. Mike Gaziano, professor of medicine at Harvard Medical School 35:13

1d ago35:13

35:13

0:00 Intro 2:00 Mike’s career prior to the Million Veteran Program (MVP), how Mike got to work on MVP, and important milestones in the project's evolution 8:30 Future goals for the Million Veteran Program in expanding and diversifying the research cohort 11:00 The roles of various omics in advancing the project's development 14:30 The most meaningf…

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EP 147: From research to delivering precision medicine in the clinic with Scott Weiss, Professor of Medicine at Harvard University 37:19

8d ago37:19

37:19

0:00 Intro to The Genetics Podcast 01:00 Welcome to Scott 01:55 Scott’s career highlights to date, ranging from epidemiology to the genetics of asthma and chronic obstructive pulmonary disease (COPD) 04:56 How and why Scott decided to transition into genetics 06:30 The advances in our understanding of the genetics of asthma and COPD over the past 2…

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Central Florida’s housing challenges and the health of homeownership — with Habitat for Humanity Orlando & Osceola and AdventHealth (podcast) 25:38

22d ago25:38

25:38

“Nine out of 10 people in Central Florida can’t afford to buy your average-priced single-family home,” according to Catherine Steck McManus, president and CEO of Habitat for Humanity Greater Orlando & Osceola County. She said it would take building about 90,000 homes tomorrow to help house everyone in need of one in Central Florida. In this episode…

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EP 146: The biology of aging with Austin Argentieri, Research Fellow at Harvard Medical School, Affiliate Member of the Broad Institute, and Research Fellow at Massachusetts General Hospital 43:05

11d ago43:05

43:05

0:00 Intro to The Genetics Podcast 01:00 Welcome to Austin 01:42 What is aging and how should we think about it? 03:50 Discussion of Austin’s recent breakthrough paper on aging, including the questions he set out to answer, and the outcomes of the research 06:32 How Austin’s work focuses on using large-scale population proteomics data to create acc…

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EP 145: Navigating rare disease drug development regulations with Daniel O’Connor 39:12

23d ago39:12

39:12

0:00 Intro to The Genetics Podcast 01:00 Welcome to Daniel 02:04 Defining rare disease in the age of personalized medicine 04:57 Key touchpoints with the Medicines and Healthcare products Regulatory Agency (MHRA) when developing a new medicine 09:27 Improvements over the course of Daniel’s career when it comes to incentivizing and making the path t…

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EP 144: Research Roundup with Dr. Veera: breakthroughs in developmental disorders, Parkinson's, SLE, and Alzheimer's 56:48

29d ago56:48

56:48

0:00 Introduction 1:40 A recurrent de novo mutation in a noncoding region of a small nucleolar RNA gene that has been identified as one of the most common causes of neurodevelopmental disorders This pathogenic variant escaped notice for years because it was not located in a protein coding region of the genome It now shows potential as a target for …

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EP 143: Harnessing human data in drug development with Jakob Steinfeldt, Co-Founder and Chief Scientific Officer at Pheiron 36:17

1M ago36:17

36:17

0:00 Intro to The Genetics Podcast 01:00 Welcome to Jakob and background on Pheiron 02:14 What made Jakob decide to start Pheiron, what the company does, and how his scientific background inspired him to found a start-up 5:24 Jakob’s excitement and inspiration around the power and potential of machine learning 07:07 Cardiology and heart failure as …

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How STROKESTRA harnesses music’s healing power for stroke survivors in Central Florida 23:27

2M ago23:27

23:27

Explore the healing power of music for stroke survivors and their families in this episode of the Inspiring Wholeness podcast, presented by AdventHealth in partnership with the Orlando Business Journal. Rich Moats, music therapist with AdventHealth, joins Rachel Moalli and Alana Jackson, two leaders with the Dr. Phillips Center for the Performing A…

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EP 142: From genome to bedside: How genetics is transforming modern medical practice with Dr. Andrea Gropman 42:45

1M ago42:45

42:45

0:00 Introduction 1:40 Andrea’s background and how she got into the field of genetics, neuroimaging, and metabolic disorders 4:00 Insights into Andrea’s clinical practice, including the diverse families and patients she serves and her approach to clinical decision-making 6:30 How genetics and genomics have changed the diagnostic journey in the last…

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EP 141: Bringing genomics to the clinic with Lori Orlando, Associate Prof at Duke University 43:24

2M ago43:24

43:24

0:00 Intro to The Genetics Podcast 01:00 Welcome to Lori Orlando 03:00 Lori’s career: From mathematical modelling to genetics and family history 05:11 The study that revealed 20% of the general population is at a higher risk of disease than average and needs preventative care 07:36 The first five diseases that Lori started analysing through informa…

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E61: Bears Legend Jim McMahon: NFL Concussions, Cannabis, & Yacht Rides in Cabo 41:43

2M ago41:43

41:43

Join host John Cerasani on a special bonus episode of 2000 Percent Raise as he sits down with legendary NFL quarterback Jim McMahon. They discuss the brutal nature of football, concussions, chronic pain, and the NFL's knowledge about brain injuries. Jim shares personal stories, including a life-threatening leg infection, dealing with post-concussio…

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Orlando Mayor Buddy Dyer and AdventHealth’s Doug Harcombe explore the “hospital of the future” and growth in Lake Nona 20:33

2M ago20:33

20:33

Orlando Mayor Buddy Dyer joins Doug Harcombe, CEO, AdventHealth Central Florida South Market/AdventHealth Lake Nona, to explore plans for the “Medical City.” They talk population growth, access to care, health tourism, innovation and the power of collaborative endeavors. Lake Nona is the perfect community for AdventHealth’s new “hospital of the fut…

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EP 140: The future of Electronic Health Records and data analysis with Ben Goldacre 52:51

2M ago52:51

52:51

0:00 Intro to The Genetics Podcast 1:00 Welcome to Ben Goldacre 02:22 Ben’s open data projects at the Bennett Institute and the challenges they aim to tackle 04:03 Using Electronic Health Records (EHR) to help the National Health Service improve care 06:18 The importance of software development within healthcare data and how to manage salary scales…

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EP 139: Rare disease breakthroughs using tRNA with Michelle Werner, CEO of Alltrna and CEO-Partner of Flagship Pioneering 44:42

2M ago44:42

44:42

0:00 Intro to The Genetics Podcast. 01:00 Welcome to Michelle. 02:00 Sstop codon diseases and how are they characterised 03:45 Diseases caused by premature stop codons in haploinsufficient genes. 04:35 The role of transfer RNA technology in finding solutions for premature stop codon diseases. 06:16 How Alltrna is engineering tRNAs which can bind to…

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EP 138: Personalised medicine using microbiome models with Dr. Almut Heinken 40:22

3M ago40:22

40:22

0:00 Introduction 1:45 Almut’s research experience, including two recent publications on genome-scale metabolic reconstruction human microorganisms Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine APOLLO: A genome-scale metabolic reconstruction resource of 247,092 diverse human microbes spanning multiple…

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EP 137: Mavis Machirori on promoting equity, diversity, and social justice in genomics research 41:40

3M ago41:40

41:40

0:00 Intro 1:30 Mavis’ career arc, from starting as a midwife to researching medical innovation and technology with an emphasis on advocacy and equity 7:00 Systemic issues that are easily overlooked in medical research and advancements Webinar: Participant Diversity: Increasing the Impact of Biomedical Research Webinar 10:00 Addressing Eurocentrici…

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EP 136: Developments in ring chromosome 20 research and advocacy with Allison Watson 40:57

3M ago40:57

40:57

0:00 Introduction 2:00 Allison’s personal journey to researching epilepsy and ring chromosome 20 syndrome 4:00 Biggest challenges families face with ring chromosome 20 syndrome 11:00 Incidence and prevalence of r(20) syndrome, and how we can improve data reliability 21:00 Applying next generation sequencing to r(20) syndrome gene research 29:00 Eng…

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Pro volleyball and breaking barriers for female athletes: Orlando Valkyries Head Coach Amy Pauly and Rothman Orthopaedics at AdventHealth’s Dr. Nicole Wilson 17:21

3M ago17:21

17:21

Volleyball — one of the fastest growing sports in the country — is pivotal in helping female athletes break through barriers, according to Amy Pauly, head coach and vice president of volleyball operations for the Orlando Valkyries, a member team of the Pro Volleyball Federation. In this episode of the Inspiring Wholeness podcast, presented by Adven…

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EP 135: Integration of newborn sequencing programs into healthcare systems with Dr. Ingrid Holm 41:16

3M ago41:16

41:16

0:00 Introduction 1:30 Ingrid’s initial interests in genetics, paediatrics, and newborn screening 2:45 How the original BabySeq project, a pioneering newborn sequencing program got started, how it’s going, and the launch of BabySeq2 8:45 Lessons from BabySeq1 and goals for BabySeq2 10:30 Potential societal and long-term considerations for those inv…

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EP 134: Prenatal genetic testing and the future of AI in genetic counselling with Kira Dineen, host of DNA Today 40:44

4M ago40:44

40:44

0:00 Introduction 1:00 The backstory of how Kira first started DNA Today in 2012, when she was still in high school! 3:30 Some of Kira’s favourite topics she has discussed on DNA Today, including the legacy of Henrietta Lacks, and the story of a Glee actress with down syndrome 10:00 Kira’s best practices for podcasting, from over 10 years of experi…

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EP 133: Insights into pharmacogenomics and increasing diversity in genomics research with Dr. Emma Magavern 39:17

4M ago39:17

39:17

0:00 Introduction 2:00 The value of an English Literature degree in designing and analysing research studies in medicine 3:45 Emma’s entrance to pharmacogenomics and her transition from practising physician to genetics research 6:00 How the East London Genes and Health program is increasing representation of diverse populations, namely South Asians…

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EP 132: From mammoths to genome editing, trailblazing genetics with Dr. George Church 47:41

4M ago47:41

47:41

0:00 Introduction 1:00 George’s upcoming big projects, including developing full recycling, renewing energy, creating bioweather maps, and harnessing citizen science 6:45 Progress in engineering viral resistance in humans, including thoughts from pre- and post- pandemic 11:00 A swapped genetic code that prevents viral infections and gene transfer b…

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Calories, gut health and food as medicine — with AdventHealth’s Karen Corbin and a local culinary medicine specialist 19:53

4M ago19:53

19:53

Your gut does not treat all calories equally. Two experts come together in a combination of health care, science and cooking to discuss this topic along with gut health and using food as medicine on this episode of the Inspiring Wholeness podcast, presented by AdventHealth in partnership with the Orlando Business Journal. Karen Corbin, Ph.D., is an…

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#182 Nicole Aimee Schreiber | Men Want to Rescue You 52:18

4M ago52:18

52:18

Stand up comedian Nicole Aimee Schreiber joins Erica Spera to talk about how being low maintenance isn't a flex, when you should and shouldn't get back with an ex, body image, how a mother's love can be harsh, and much more...Use Promo Code SGS20 for 20% off ⁠⁠⁠SunsetLakeCBD.com⁠⁠⁠ Join the Patreon to support the show and for extra episodes: ⁠⁠⁠⁠⁠⁠…

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EP 131: The potential of somatic genomics in drug discovery and development with Jake Rubens 44:57

4M ago44:57

44:57

0:00 Intro 0:40 Jake’s experiences as a serial entrepreneur starting five companies with a basis in genomic science 5:30 Opportunities for research and drug development in the realm of somatic science 9:20 Somatic evolution and how it provides valuable insights into disease mechanisms 12:30 Advantages and disadvantages of studying germline genome-w…

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EP 130: Quarterly insights into noncoding variants and GWAS with Dr. Veera Rajagopal 51:56

5M ago51:56

51:56

Show Notes: 0:00 Introduction 1:20 How polydactyl mutations can inform research on non-coding variant mechanisms The importance of low-affinity binding between transcription factors and targets How these lessons can help us improve our understanding of drug and target discovery See Veera’s January round-up for more information: https://www.gwasstor…

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EP 129: Patient advocacy for genetic ALS and FTD with Jean Swidler, Executive Director of End the Legacy 38:44

5M ago38:44

38:44

0:00 Introduction 0:45 Jean’s personal experiences with family members with genetic ALS 10:00 Jean’s thoughts on the barriers and facilitators to providing treatment for those with genetic ALS 13:20 Insights into C9orf72, a common genetic determinant of ALS, and how it can also be associated with FTD 16:10 Jean’s experiences as an active advocate f…

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E60: Decisions in Real Estate 20:41

5M ago20:41

20:41

This week John is coming at you 1:1 before taking a short break. He highlights some of his favorite moments from Season 2 and teases The Partner, an upcoming project described as a mix of 'The Apprentice' & 'Shark Tank' with John’s in-your-face personality that is more frequent on his social media. The Partner will be available soon on John Cerasan…

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EP 128: Parkinson’s disease and precision medicine with Drs. James Beck and Ignacio Mata 50:18

5M ago50:18

50:18

0:00 Introduction 1:05 Insights into the PD GENEration’s (a programme from the Parkinson's Foundation) milestones and progress points for the upcoming year 3:30 The shifting attitudes and perspectives of neurologists and healthcare workers at the PD GENEration 5:50 Insights into Nacho’s work with the genetics of Parkinson’s disease 10:20 Barriers a…

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Sheriff Dennis Lemma and AdventHealth Hope & Healing Center’s Scott Tucker share one solution to drastically reduce drug-related illnesses and deaths in Central Florida 26:08

5M ago26:08

26:08

In this episode of the Inspiring Wholeness podcast, presented by AdventHealth in partnership with the Orlando Business Journal, Seminole County Sheriff Dennis Lemma joins Scott Tucker, Ph.D., clinical director of operations for AdventHealth Hope & Healing Center, to discuss how the substance abuse treatment center is making an impact on drug-relate…

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E59: Andrew Hurst & Pat Miletich: Debunking Myths About Fitness, Health, and Nutrition 1:12:12

5M ago1:12:12

1:12:12

This week we kick things off with an engaging interview with the one and only Andrew Hurst for a deep dive into all things health and wellness. From shedding light on the Atkins diet to sharing success stories of training former NFL players, Andrew doesn't hold back when it comes to dishing out valuable insights. Plus, he reveals the secrets of the…

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EP 127: Insights into precision medicine, fatty liver disease, and minimally invasive diagnostic tools with Dr. Mazen Noureddin 39:10

5M ago39:10

39:10

0:00 Intro 0:25 Mazen’s lifelong commitment to furthering the field of precision medicine in liver disease research, fueled by a personal connection of his grandmother developing MASH cirrhosis 2:30 Breakthroughs in the field of metabolic dysfunction-associated steatotic liver disease (MASLD) since the beginning of Mazen’s career 5:30 The potential…

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E58: Revenue Generation at SPEED & SCALE with Conner & Cavin | Bonus interview with Nicole Vallance 1:23:43

5M ago1:23:43

1:23:43

This week we are shaking things up a bit with a duo of conversations about the art & science of sales and cold calling and the importance of faith in leadership. We kick things off with a great talk with two younger entrepreneurs, Cavin Sherman, and Conner Fredrickson, the co-founders of Exodus Sales Collective. These guys bring a sharp business ac…

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EP 126: Patient-led research for ultra-rare disease drug development with Julia Taravella, Executive Director of Rare Trait Hope Fund 39:41

6M ago39:41

39:41

0:00 Introduction 0:25 Julia’s personal experience with ultra-rare diseases within her family 10:25 The importance of increasing accessibility to genetic testing across populations to learn more about ultra-rare diseases 14:00 The origin story of Rare Trait Hope Fund 23:50 Current research and next steps in developing potential gene therapies for a…

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WFTV’s Greg Warmoth joins AdventHealth’s Dr. Mark Socinski to discuss his journey with cancer — and how he hopes his message will save others 26:01

6M ago26:01

26:01

Greg Warmoth, long-time WFTV anchor, shares his journey with lip cancer — a tale of caution and hope — in this episode of the Inspiring Wholeness podcast, presented by AdventHealth in partnership with the Orlando Business Journal. He’s joined by Dr. Mark Socinski, executive medical director of the AdventHealth Cancer Institute. Listen to this episo…

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E57: A Conversation with Sarena Souza, Jon Orlando, and John Cerasani About Losing a Parent 33:37

6M ago33:37

33:37

This week 2000 Percent Raise takes a heartfelt turn as we explore the emotional landscape of loss and caregiving with our guests, the host of The Action Junkeez Podcast Jon Orlando, and his friend and Mother’s hospice CNA caregiver, Sarena Souza. John anchors a heartfelt discussion that takes a critical look at employee long-term disability plans a…

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EP 125: The future of UK Clinical Trial Policy: Innovation, integration, and game-changing legislation with Lord James O’Shaughnessy 45:23

6M ago45:23

45:23

0:00 Introduction 1:25 How Lord O’Shaughnessy became involved in scientific policy making and his path to writing the UK Commercial Clinical Trials Review. 04:05 How Lord O’Shaughnessy pivoted from education to a focus on life sciences 06:38 The biggest challenges Lord O’Shaughnessy faced during his time as Parliamentary Under Secretary for Health …

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E56: Brad Lea: A Debate on Gurus & Influencers 52:37

6M ago52:37

52:37

This week John swings by the Dropping Bombs Podcast Studio in Las Vegas for a discussion with Brad Lea on a multitude of topics covering the realms of entrepreneurship, social media influence, content creation, and personal development. For many listeners Brad needs no introduction, he is a massively influential thought leader, author, CEO, social …

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EP 124: How ReCode Therapeutics is pioneering tissue specific delivery of gene therapies for Primary Ciliary Dyskinesia with John Matthews 42:00

6M ago42:00

42:00

0:00 Introduction 01:10 How growing up in Malawi planted the seeds for John’s career in medicine and transition to therapeutic development 04:35 Why John focuses on rare diseases and conditions such as asthma 06:01 What has changed over the last decade in terms of treating and understanding asthma and the progress that genetics has enabled 07:31 Wh…

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E55: John Cerasani & Mark Holman: As Is Football, as Is Business, as Is Life. 47:45

6M ago47:45

47:45

We are back this week with another candid convo with John, as he dives deep with our latest guest, Mark Holman. Mark is a seasoned entrepreneur, domain name connoisseur, and a compassionate coach. He is the founder and CEO of Datafied Global and Order Medical Records.com. In this chat, Mark and John pull back the curtain on the quirky contrasts in …

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EP 123: The ethics of newborn genome screening: Actionable insights and beyond with Holly Peay, Senior Research Scientist at the Research Triangle Institute 45:34

6M ago45:34

45:34

0:00 Introduction 0:50 Holly’s background and career so far 03:30 Complex decision-making and multiple risk factors: Family history, genetics, phenotypes and beyond 07:05 Changes within the last decade to help people make complex, sometimes subjective, healthcare decisions 09:20 Impact on people: The RTI’s mission and the Early Check Study 13:45 Ne…

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Making generational changes in the West Lakes community — with Lift Orlando’s Eddy Moratin and AdventHealth for Children’s Alfreda Clark 24:26

6M ago24:26

24:26

There’s a startling message on Lift Orlando’s website: “ZIP code is the No. 1 predictor of life outcomes.” Eddy Moratin, Lift Orlando president, and Alfreda Clark, director of AdventHealth for Children's West Lakes Early Learning Center, came together to discuss changing that statistic, particularly in the West Lakes neighborhood outside of Camping…

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E54: Anthony Ficarra: Maximizing Your Financial Future 32:36

6M ago32:36

32:36

We're back at it again with another eye-opening convo, and this time it's all about the Benjamins – well, protecting them, actually! Anthony Ficarra swings by to school listeners on the ins and outs of life insurance and why it's not just a rich person's game. John kicks things off, introducing Anthony as a champ in the life insurance scene who doe…

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EP 122: Building genome-scale engineered cells for biotechnology with Leslie Mitchell, Co-founder and CEO of Neochromosome 35:55

7M ago35:55

35:55

Summary: 0:00 Introduction 01:01 How Leslie got into the field of synthetic biology and engineering, and her career journey so far 02:45 What Leslie accomplished during her postdoc and recent transformations in the field of genomics 05:57 The impacts of non-coding regions of the genome and the outcome of deletions 08:20 How long it takes to make ch…

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E53: Cypress Hill: Behind the Bong with Sen Dog 36:55

7M ago36:55

36:55

This week 2000 Percent Raise hits another High Note with an exclusive sit-down with the one and only legend Sen Dog from the iconic Hip-Hop Group Cypress Hill. Alongside his Manager Trace, Sen Dog unpacks a treasure trove of stories touching on everything from the towering heights of music success to the legacy of Cypress Hill. Listeners are in for…

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EP 121: Breakthroughs and insights in ALS research with Dr. Michael Benatar 44:10

7M ago44:10

44:10

Summary: 0:00 Introduction 0:50 Reflections from the 34th International Symposium on ALS/MND in Basel 1:50 Michael’s professional journey, initial challenges he encountered, and how the field of neurology has evolved over the years 3:10 An introduction to the ALS landscape, including its presentation, the genes involved, and potential treatment opt…

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NASCAR’s Jimmie Johnson and Erik Jones: Hitting the track in Daytona, partnering with AdventHealth, and beyond racing 23:23

7M ago23:23

23:23

NASCAR’s Jimmie Johnson and Erik Jones join Audrey Gregory, Ph.D., R.N., executive vice president and CEO for the AdventHealth East Florida Division, in this episode of the Inspiring Wholeness podcast, presented by AdventHealth in partnership with the Orlando Business Journal. They discussed AdventHealth’s new partnership with NASCAR Cup Series tea…

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E52: Business. Sports. Marriage. Featuring Austin Ekeler 38:58

7M ago38:58

38:58

2000 Percent Raise returns with a no-holds-barred interview with Austin Ekeler, dynamic NFL running back for the Los Angeles Chargers! Austin sits down with John to give listeners an insider's look into the high-stakes world of NFL player negotiations. Austin sheds light on his role in the executive committee and the complex interplay between the N…

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EP 120: Exploring the frontiers of gene therapy and AAVs with Dr. Nicole Paulk, CEO and Founder of Siren Biotechnology 43:47

7M ago43:47

43:47

0:00 Introduction to Dr. Nicole Paulk, a pioneer in AAV research and the founder of Siren Biotechnology 0:50 The moments that shaped Nicole’s career path and her passion for gene therapy and AAV research 9:20 Nicole’s academic research career and her transition from academia to the biotech industry 23:00 The story behind the founding of Siren Biote…

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