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תוכן מסופק על ידי by the FLCCC Alliance and By the FLCCC Alliance. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי by the FLCCC Alliance and By the FLCCC Alliance או שותף פלטפורמת הפודקאסט שלו. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
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DrBeen#84: Researchers Find Flaws with mRNA Therapeutics

40:21
 
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Manage episode 396016898 series 3514482
תוכן מסופק על ידי by the FLCCC Alliance and By the FLCCC Alliance. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי by the FLCCC Alliance and By the FLCCC Alliance או שותף פלטפורמת הפודקאסט שלו. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.

An article from the University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics." Let’s review.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

Reference list from Dec. 8, 2023
Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge
https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature
https://www.nature.com/articles/s41586-023-06800-3

The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next

Ribosomes, Transcription, Translation | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized

Genetic code - Wikipedia
https://en.wikipedia.org/wiki/Genetic_code

DNA and RNA codon tables - Wikipedia
https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables

Pseudouridine - Wikipedia
https://en.wikipedia.org/wiki/Pseudouridine

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science
https://pubs.acs.org/doi/10.1021/acscentsci.1c00197

Ribonucleotide - Wikipedia
https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA

Translation: DNA to mRNA to Protein | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life

Frontiers | On programmed ribosomal frameshifting: the alternative proteomes
https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift)

Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

  continue reading

263 פרקים

Artwork
iconשתפו
 
Manage episode 396016898 series 3514482
תוכן מסופק על ידי by the FLCCC Alliance and By the FLCCC Alliance. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי by the FLCCC Alliance and By the FLCCC Alliance או שותף פלטפורמת הפודקאסט שלו. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.

An article from the University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics." Let’s review.

DrBeen: Medical Education Online
https://www.drbeen.com/

FLCCC | Front Line COVID-19 Critical Care Alliance
https://covid19criticalcare.com/

Reference list from Dec. 8, 2023
Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge
https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses

N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature
https://www.nature.com/articles/s41586-023-06800-3

The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next

Ribosomes, Transcription, Translation | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized

Genetic code - Wikipedia
https://en.wikipedia.org/wiki/Genetic_code

DNA and RNA codon tables - Wikipedia
https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables

Pseudouridine - Wikipedia
https://en.wikipedia.org/wiki/Pseudouridine

Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science
https://pubs.acs.org/doi/10.1021/acscentsci.1c00197

Ribonucleotide - Wikipedia
https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA

Translation: DNA to mRNA to Protein | Learn Science at Scitable
https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life

Frontiers | On programmed ribosomal frameshifting: the alternative proteomes
https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift)

Disclaimer:This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

  continue reading

263 פרקים

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