Health Discourse with Sakshi & Sushant- Episode 10

Genefitletics

Metabolic disease is taking a giant leap forward with the number of people developing obesity, type 2 diabetes & more is increasing. Although we have all resources & tech in place, still we do not have any preventative solutions to stop these diseases from developing in the first place. There is need to understand -Food processing, farming practices & industrial practices to improve the shelf life: Although labels will show the same value, processed foods such as rolled oats or commercially grinded nuts would be processed differently. Besides, it is also important to decode the functions of your microbiome as 99% of biological functions are performed by them. The interaction between food & microbiome also determine how each food is processed, how much calories are extracted what byproducts is produced as a result - Glycemic response to various foods: Over the last 2 years, we have seen a number of companies coming up with continuous glucose monitoring machines but there are multiple structure & functional issues associated with CGM. CGM are not more that a guess work -CGM measures your glycemic response to various foods post its consumption, does not predict glucose spike -CGM measures response to a meal, not food, not specific molecules in food. We really need to understand how each of molecule contribute to our blood sugar response -You may fix CGM for 2-3 weeks to make a list of food that is going to spike more than others & may consider it static for you. However, as you feed your microbiome, functional pathways & composition changes, glycemic response to food changes & therefore you need to track glycemic response every month, making you endlessly spend on CGM every month. -CGM does not tell you why you have a glycemic response to specific foods as it does not decode the interaction between food you eat & your gut/oral microbiome. - Rather than just tracking glycemic response using CGM, the focus is on understanding the level of production of nitric oxide(which is a signal that tells GLUT 4 to clear the glucose from the circulation, LPS Production, TMAO, P-cresol & more. Our today’s talk discusses in detail We at Genefitletics, based on functional pathways of gut & oral microbiome measure & quantify 17 pls microbial pathways to predict onset & progression of type 2 diabetes & even predict insulin response to 317 foods. More details here: www.genefitletics.com