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P-Tau in CSF Extracellular Vesicles in Alzheimer’s disease [A.I.]
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Manage episode 446870742 series 3609751
תוכן מסופק על ידי Gavin Thomas. כל תוכן הפודקאסטים כולל פרקים, גרפיקה ותיאורי פודקאסטים מועלים ומסופקים ישירות על ידי Gavin Thomas או שותף פלטפורמת הפודקאסט שלהם. אם אתה מאמין שמישהו משתמש ביצירה שלך המוגנת בזכויות יוצרים ללא רשותך, אתה יכול לעקוב אחר התהליך המתואר כאן https://he.player.fm/legal.
STUDY:
Sattarov, R., Havers, M., Orbjörn, C. et al. Phosphorylated tau in cerebrospinal fluid-derived extracellular vesicles in Alzheimer’s disease: a pilot study. Sci Rep 14, 25419 (2024). https://doi.org/10.1038/s41598-024-75406-0
Findings: This research paper investigates the potential of extracellular vesicles (EVs), tiny membrane-bound sacs secreted by cells, as biomarkers for Alzheimer's disease (AD). The study used a novel technique called acoustic trapping to isolate EVs from cerebrospinal fluid (CSF) of AD patients and cognitively unimpaired controls. The researchers found that the levels of phosphorylated tau (P-tau), a protein associated with AD pathology, differed significantly between the two groups in EVs isolated from CSF. Specifically, EVs from AD patients showed higher levels of P-tau181 and lower levels of P-tau217, leading to a higher P-tau181/P-tau217 ratio compared to controls. These findings suggest that EVs could play a role in the spread of AD pathology and may serve as potential biomarkers for early disease detection.
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