S2/E112. What's Coming in Obesity Medicine? The Med Pipeline with Dr. Sean Wharton

High on Life

What new medications are coming down the pipeline in Obesity Medicine? I explore the latest and greatest in obesity pharmacotherapy with my guest today, Dr. Sean Wharton.

Dr. Wharton is one of the leading Canadian researchers in Obesity Medicine. He is co-lead author of the Canadian Obesity Guidelines and the primary author of many of the clinical trials in bariatric medicine and type 2 diabetes. We discussed what is being studied in Phase 2 and 3 clinical trials in obesity management including:

• Semaglutide (Wegovy/Ozempic)
• Tirzepatide (Mounjaro/Zepbound)
• Retatrutide (GLP1, GIP, glucagon triple analogue)
• Cagrisema (amylin/GLP1 dual analogue)
• Bimagrumab (human monoclonal antibody)
• Cannabinoid-receptor antagonists (CB1)
• Orforglipron
• Oral GLP1 peptides
• Medications taken once monthly

**A small error that Dr. Wharton wanted to correct. The Amgen molecule discussed today is a GIPR antagonist, not a glucagon antagonist.

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