Weight Changes Associated with Antidepressants

Mayo Clinic Talks

Host: Darryl S. Chutka, M.D. [@chutkaMD]

Guest: Mark A. Frye, M.D.

We have a variety of antidepressant medications available to us including SSRI’s, SNRI’s and others, and for the most part they’re very well tolerated by our patients. They are much better tolerated compared to some of our older options such as the tricyclic antidepressants and MAO inhibitors. These older products often produced cardiovascular and anticholinergic adverse effects, not commonly seen with our newer medications. However, our newer antidepressants do have a relatively common adverse effect. They tend to produce weight changes, usually a weight increase. Which antidepressants tend to produce the most weight gain? How much weight does the typical patient gain from these medications? Is the weight gained typically maintained or lost when the medication is stopped? In this podcast, I’ll be discussing these questions and more with Mark A. Frye, M.D., a psychiatrist at the Mayo Clinic.

To learn more about this topic: https://pubmed.ncbi.nlm.nih.gov/38950403/

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