EP 151: Understanding cell ageing and its role in disease with Marco Quarta Co-founder and CEO of Rubedo Life Sciences

The Genetics Podcast

0:00 Intro to The Genetics Podcast

01:00 Welcome to Marco

02:00 The areas Marco focused on during his academic career and what motivated him to found his first company

03:18 How our understanding of ageing has changed over the past two decades and some of the current big questions in ageing biology

06:01 How to get a clearer picture of the ageing process within a tissue or cell and if new technologies like single cell genomics can aid this process

11:08 Catalyst or cause? Understanding the role of cellular senescence in disease and how it impacts treatment pathways

12:54 The challenges of building a company that addresses an area of biology which sits at the core of so many diseases and disease types

16:17 Deciding on which therapeutic modality to target when using a platform biology approach

17:57 Identifying the most effective stage at which to intervene in the senescence process and if this changes dependent upon organ system or disease area

24:33 How another company founded by Marco, Turnbio, uses a different approach by focusing on turning back the biological clock rather than understanding the ageing process and intervening

31:08 Addressing if both preventative and intervention approaches are required to comprehensively treat or cure a disease

35:39 Whether there is potential to develop core therapeutics which can have a system-wide effect and address all-cause ageing

40:12 Why ‘biohacking’ therapies can present a risk to the field of ageing biology as a whole, as well as to individuals

41:18 The developing area of science or technology Marco is most excited about and which he believes is going to have a significant impact in the coming years

43:23 Closing remarks

Find out more

www.rubedolife.com