502. When IVF Fails: Understanding Antiphospholipid Syndrome and When to Seek a Second Opinion

The IVF Journey with Dr Michael Chapman

In this episode, Prof Chapman answers a listener’s question about antiphospholipid syndrome (APAS) and how it can affect IVF outcomes. He explains how immune-related conditions increase miscarriage risk, and why treatments like heparin and steroids can improve success rates when properly managed. Prof Chapman also shares valuable insights on what to do after a failed IVF cycle—when to change protocols, consider a new clinic, or simply keep trying. His key message: don’t lose hope—persistence, proper review, and the right expertise make all the difference.

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