504. The Breakthrough that Changed Everything: How ICSI Transformed Male Infertility

The IVF Journey with Dr Michael Chapman

In this episode, Prof Chapman reflects on the most remarkable breakthrough in his decades-long career — the introduction of intracytoplasmic sperm injection (ICSI) in the early 1990s. He explains how this single innovation revolutionised treatment for men with low or even absent sperm counts, making fatherhood possible where it once seemed impossible. Prof Chapman also traces the evolution of IVF success rates from just 10% in the 1980s to over 40% today, highlights the game-changing impact of embryo freezing, and discusses why global consistency in IVF ethics and regulation remains a challenge.

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